中国药理学通报2025，Vol.41Issue(12)：2246-2252,7.DOI:10.12360/CPB202505083
人参皂苷Rg1通过抑制AIM2/NLRP3炎症小体改善小鼠心肌慢性炎症损伤及纤维化
Ginsenoside Rg1 improves chronic myocardial inflammatory injury and fibrosis by inhibiting AIM2/NLRP3 inflammasomes in mice
摘要
Abstract
Aim To investigate the protective role and mechanism of ginsenoside Rg1 in myocardial inflamma-tion injury and fibrosis induced by chronic lipopolysac-charide(LPS)exposure in mice.Methods A chro-nic LPS-induced mouse model was established and ran-domly assigned to six groups:control,LPS(200 μg·kg-1),Rg1(5,10,20 mg·kg-1)and Tempol(50 mg·kg-1)groups.Cardiac function was evaluated by using echocardiography,and histopathological changes in myocardial tissue were assessed via hematoxylin-eo-sin(HE)staining,Masson's trichrome staining,and periodic acid-Schiff(PAS)staining.The expression levels of TRPC6,AIM2,NLRP3,cleaved caspase-1,IL-1β,and IL-6 were detected by Western blotting.Results Compared with the control group,the cardiac function of LPS group significantly decreased,the de-gree of myocardial injury and fibrosis was aggravated,and the expressions of TRPC6,AIM2,NLRP3,IL-1 βand IL-6 significantly increased.Compared with the LPS model group,Rg1 treatment significantly improved the cardiac function,alleviated myocardial injury and fibrosis,and inhibited the expression of TRPC6,the activation of AIM2/NLRP3 inflammasomes and the ex-pression of inflammatory factors.Conclusions Gin-senoside Rg1 can inhibit the activation of AIM2/NL-RP3 inflammasomes by down-regulating TRPC6 signa-ling,thereby reducing the chronic myocardial inflam-matory injury and fibrosis caused by chronic LPS expo-sure.关键词
人参皂苷Rg1/AIM2炎症小体/NLRP3炎症小体/心肌纤维化/脂多糖/TRPC6/慢性炎症Key words
ginsenoside Rg1/AIM2 inflammasome/NLRP3 inflammasome/myocardial fibrosis/lipopo-lysaccharide/TRPC6/chronic inflammation分类
医药卫生引用本文复制引用
樊嫘,朱幸,梁浩宇,黄蕾,李卫平,李维祖..人参皂苷Rg1通过抑制AIM2/NLRP3炎症小体改善小鼠心肌慢性炎症损伤及纤维化[J].中国药理学通报,2025,41(12):2246-2252,7.基金项目
国家自然科学基金资助项目(No 81970630) （No 81970630）
安徽省自然科学基金资助项目(No 2208085MH219) （No 2208085MH219）
