中国医院用药评价与分析2025，Vol.25Issue(11)：1312-1317,6.DOI:10.14009/j.issn.1672-2124.2025.11.007
基于网络药理学的润伊容胶囊治疗痤疮的作用机制研究
Mechanism of Runyirong Capsules in the Treatment of Acne Based on Network Pharmacology
摘要
Abstract
OBJECTIVE:To explore the pharmacological material basis of Runyirong capsules and its potential mechanism in the treatment of acne based on the network pharmacology method.METHODS:The active components and the action targets in Runyirong capsules were screened through the traditional Chinese medicine systems pharmacology database and analysis platform(TCMSP),while the related disease targets of acne were simultaneously obtained from GeneCards,DrugBank and OMIM databases.Multi-dimensional network models were established with the help of Cytoscape software,including the component-predicted target network,protein-protein interaction(PPI)network,disease-component-potential target network,and component-target-pathway network.The potential target genes were subjected to gene ontology(GO)functional enrichment analysis and Kyoto encyclopedia of genes and genomes(KEGG)pathway enrichment analysis by using the Rstudio software.RESULTS:A total of 37 compounds were obtained through systematic screening,corresponding to 640 potential action targets.There were 970 acne-related targets and 175 intersectional targets of Runyirong capsules and acne.PPI network analysis revealed that key targets such as epidermal growth factor receptor,sarcoma kinase,tumor necrosis factor(TNF),peroxisome proliferator-activated receptor γ,and protein kinase B were located at the core of the network.The GO functional enrichment analysis mainly covered 2 898 biological processes.The KEGG pathway enrichment results indicated that its mechanism was associated with 148 signaling pathways such as lipid and atherosclerosis,advanced glycation end(AGE)product-AGE receptor signal transduction,Th17 cell differentiation,NOD-like receptors,and TNF signal transduction.CONCLUSIONS:The basic pharmacological effects of Runyirong capsules and its mechanism of action in the treatment of acne have been preliminarily verified,providing theoretical references and research directions for the clinical application of Runyirong capsules.关键词
痤疮/润伊容胶囊/网络药理学/分子对接Key words
Acne/Runyirong capsules/Network pharmacology/Molecular docking分类
医药卫生引用本文复制引用
赵彤,周纪颖,乔川琪,李嘉琪,杨思昀,柴克燕,王郝嘉,王辉,吴嘉瑞..基于网络药理学的润伊容胶囊治疗痤疮的作用机制研究[J].中国医院用药评价与分析,2025,25(11):1312-1317,6.基金项目
国家中医药管理局高水平中医药重点学科建设项目(No.zyyzdxk-2023257) （No.zyyzdxk-2023257）
