中国医院用药评价与分析2025，Vol.25Issue(11)：1325-1327,1331,4.DOI:10.14009/j.issn.1672-2124.2025.11.009
酸枣仁在虚烦型失眠治疗中的用药剂量与疗效关系探析
Dose-Response Analysis of Ziziphi Spinosae Semen in the Treatment of Xufan-Type Insomnia
摘要
Abstract
OBJECTIVE:To probe into the correlation between the dosage and clinical efficacy of Ziziphi spinosae semen in the treatment of Xufan-type insomnia,and to identify the optimal therapeutic dose and safety profile.METHODS:A randomized controlled trial method was used,100 patients diagnosed with Xufan-type insomnia in the hospital from 2022 to 2023 were exacted to be divided into the conventional-dose group(Ziziphi spinosae semen for 15 g/d)and high-dose group(Ziziphi spinosae semen for 30 g/d)according to the random number table method,with 50 cases in each group.The treatment duration for both groups was 14 d.Pittsburgh Sleep Quality Index(PSQI),traditional Chinese medicine symptom scores,clinical efficacy,and adverse drug reactions were observed before and after treatment.RESULTS:After treatment,the PSQI scores and traditional Chinese medicine symptom syndrome scores of both groups were significantly lower than those before treatment,and the high-dose group was greater than the conventional-dose group,the differences were statistically significant(P＜0.01).The total effective rate of the high-dose group was 94.0％(47/50),significantly higher than 80.0％(40/50)of the conventional group,the difference was statistically significant(P=0.043).No severe adverse drug reactions were reported in either group.CONCLUSIONS:Ziziphi spinosae semen demonstrates significant efficacy in the treatment of Xufan-type insomnia.Moreover,the 30 g/d Ziziphi spinosae semen is more advantageous in improving sleep quality and alleviating traditional Chinese syndrome compared with the 15 g/d.It is also safe and controllable,and clinical use of higher doses is recommended based on patients' condition.关键词
酸枣仁/虚烦型失眠/剂量-效应/随机对照试验/匹兹堡睡眠质量指数/中医证候积分Key words
Ziziphi spinosae semen/Xufan-type insomnia/Dose-response/Randomized controlled trial/Pittsburgh Sleep Quality Index/Traditional Chinese medicine分类
医药卫生引用本文复制引用
文霞,王和平,周智春,李晓芳..酸枣仁在虚烦型失眠治疗中的用药剂量与疗效关系探析[J].中国医院用药评价与分析,2025,25(11):1325-1327,1331,4.基金项目
国家中医药管理局全国名老中医药专家传承工作室项目(No.国中医药人教函[2022]75号) （No.国中医药人教函[2022]75号）
四川省中医药管理局科学技术研究专项课题(No.2020LC0217) （No.2020LC0217）
