中国中西医结合外科杂志2025，Vol.31Issue(6)：811-821,11.DOI:10.3969/j.issn.1007-6948.2025.06.002
扶正解毒法治疗非肌层浸润性膀胱癌术后灌注相关下尿路症状的临床效果
Therapeutic effect observation of Fuzheng Jiedu method in the treatment of postoperative infusion-related lower urinary tract symptoms of non-muscle invasive bladder cancer
摘要
Abstract
Objective To observe the therapeutic effect of Fuzheng Jiedu decoction on lower urinary tract symptom in patients with non-muscle invasive bladder cancer(NMIBC).Methods A total of 80 NMIBC patients who underwent intravesical instillation were enrolled in this cohort study,including 40 patients from Guang'anmen Hospital of China Academy of Chinese Medical Sciences and 40 patients from Peking University First Hospital from April 2023 to December 2023.Patients in both groups received postoperative adjuvant perfusion drugs.The traditional Chinese medicine group was treated with intravesical instillation combined with Professor Lu Jianxin' s Fuzheng Jiedu decoction.The OABSS score,CLSS score and other scores,the disappearance time of lower urinary tract symptoms and the incidence of adverse reactions were compared between the two groups.Results The scores of the two groups at different follow-up time points were improved,and the differences were statistically significant(P<0.05).The improvement of scores in the TCM group was better than that in the control group,and the differences were statistically significant(P<0.05).There were significant differences in the disappearance time of lower urinary tract symptoms between the two groups at 3 months and 6 months of follow-up in the overall analysis,6 months of follow-up in the pirarubicin subgroup analysis,the first follow-up,1 month of follow-up,and 3 months of follow-up in the BCG subgroup analysis(P<0.05),and the disappearance time of urinary urgency in the TCM group was better than the control group.During the follow-up period,the adverse reactions of diarrhea in the two groups were statistically significant(P<0.05).Conclusion Fuzheng Jiedu decoction can effectively improve the lower urinary tract symptoms of NMIBC patients after postoperative perfusion,especially urgency.It can effectively improve a variety of urination scores in patients with postoperative perfusion of NMIBC,and has advantages in clinical efficacy and certain safety.关键词
扶正解毒法/非肌层浸润性膀胱癌/膀胱灌注/下尿路症状Key words
Fuzheng Jiedu method/non-muscle invasive bladder cancer/intravesical instillation/lower urinary tract symptoms分类
医药卫生引用本文复制引用
王自强,卢建新..扶正解毒法治疗非肌层浸润性膀胱癌术后灌注相关下尿路症状的临床效果[J].中国中西医结合外科杂志,2025,31(6):811-821,11.基金项目
中央高水平中医医院临床研究和成果转化能力提升项目——临床科研一体化人才专项(外科团队培育项目)(HLCMHPP2023125) （外科团队培育项目）
