中国中药杂志2025，Vol.50Issue(21)：5948-5955,8.DOI:10.19540/j.cnki.cjcmm.20250725.601
化痰解毒中药抗肿瘤临床应用与机制研究现状
Current status of clinical application and mechanism research of traditional Chinese medicine for resolving phlegm and detoxifying in anti-tumor treatment
摘要
Abstract
Malignant tumors,as a major public health issue facing the world,have extremely complex pathogenesis.Molecular biology features represented by acidic microenvironment and lipid metabolism disorders are closely related to tumor invasion and metastasis.Traditional Chinese medicine(TCM)holds that the diseases caused by phlegm toxicity are characterized by heaviness,turbidity,stickiness,and difficulty in resolving.Modern pharmacological research has confirmed that as a TCM for resolving phlegm and detoxifying to treat phlegm toxicity,it can not only exert anti-cancer effects by directly inhibiting tumor cell proliferation but also reshape the steady-state regulatory network of the tumor microenvironment,including downregulating the microenvironment of lactate accumulation mediated by hypoxia-inducible factor 1α(HIF-1α)and regulating fatty acid synthase(FASN)-related lipid metabolism reprogramming processes,thereby antagonizing tumor invasion and metastasis.The innovative TCM theory of cancer toxicity pathogenesis proposed by our team suggests that the pathogenic characteristics of phlegm toxicity are homologous to the pathological accumulation of abnormal metabolites in the tumor microenvironment.This study systematically reviews the relevant literature on the treatment of tumors with TCM for resolving phlegm and detoxifying,deeply analyzes the theoretical basis of TCM,summarizes the clinical experience of famous TCM practitioners,and explores the clinical efficacy of TCM for resolving phlegm and detoxifying against tumors.At the same time,this study objectively summarizes its active ingredients and anti-tumor mechanisms,so as to provide reference for the prevention and treatment of malignant tumors with TCM.关键词
化痰解毒/恶性肿瘤/临床应用/机制研究Key words
resolving phlegm and detoxifying/malignant tumor/clinical application/mechanism research引用本文复制引用
卜岍岍,张冠南,李柳,陆思丞,孙东东,程海波..化痰解毒中药抗肿瘤临床应用与机制研究现状[J].中国中药杂志,2025,50(21):5948-5955,8.基金项目
国家重点研发计划"中医药现代化"重点专项(2022YFC3500200,2022YFC3500204) （2022YFC3500200,2022YFC3500204）
国家中医药管理局中医药创新团队及人才支持计划项目(ZYYCXTD-C-202208) （ZYYCXTD-C-202208）
江苏高校"青蓝工程"资助项目(苏教师函[2023]27号) （苏教师函[2023]27号）
中医肿瘤癌毒病机揭榜挂帅专项(AD202402) （AD202402）
江苏省自然科学基金青年项目(BK20240735) （BK20240735）
