中国中药杂志2025，Vol.50Issue(21)：5978-5986,9.DOI:10.19540/j.cnki.cjcmm.20250620.201
α-细辛醚抗癫痫的药理作用及机制研究进展
Progress in pharmacological effects and mechanisms of α-asarone against epilepsy
摘要
Abstract
Epilepsy is a clinical syndrome caused by abnormal synchronous discharges of neurons in the brain resulting from multiple etiological factors.Its pathogenesis is complex,and the number of patients is increasing year by year.Existing antiepileptic drugs have problems of drug resistance and various adverse reactions,making it difficult to completely and effectively control the persistent or recurrent seizures of epilepsy.This has become an important issue urgently needing resolution in the field of epilepsy treatment.α-Asarone is an active component of the volatile oil of Acori Tatarinowii Rhizoma.Studies have shown that α-asarone exerts therapeutic effects against epilepsy through multiple mechanisms,including anti-apoptosis,anti-inflammation,antioxidation,regulation of neurotransmitter balance,modulation of ion channels,and protection of the blood-brain barrier.The synergistic effect among these mechanisms reflects the unique advantages of α-asarone in multi-level,multi-target,and comprehensive treatment.Therefore,this article reviews the relevant pharmacological mechanisms of α-asarone in epilepsy treatment and the synergistic effects among these mechanisms by searching relevant literature in China and abroad,aiming to provide a theoretical basis for the basic research and clinical application of α-asarone.关键词
癫痫/α-细辛醚/细胞凋亡/氧化应激Key words
epilepsy/α-asarone/apoptosis/oxidative stress引用本文复制引用
开胤桦,杨欣,杨旭红,田茸,蒋萃..α-细辛醚抗癫痫的药理作用及机制研究进展[J].中国中药杂志,2025,50(21):5978-5986,9.基金项目
国家自然科学基金面上项目(81973929) （81973929）
成都中医药大学"杏林学者"学科人才科研提升计划项目(MPRC2022003) （MPRC2022003）
四川省中管局2024年度中医药科研专项(2024MS569) （2024MS569）
