中国中药杂志2025，Vol.50Issue(22)：6205-6214,10.DOI:10.19540/j.cnki.cjcmm.20250729.601
脂质体递送神经保护剂治疗缺血性脑卒中的研究进展
Advances in liposome-delivered neuroprotective agents in treatment of ischemic stroke
摘要
Abstract
The clinical efficacy of ischemic stroke is severely limited by the difficulty in targeted delivery of neuroprotective agents across the blood-brain barrier to the ischemic region.Liposomes,with their unique bilayer structure,can carry both hydrophilic and hydrophobic drugs and have excellent biocompatibility,modifiability,and high efficiency in crossing the blood-brain barrier,which have become a key strategy to break through the bottleneck of drug delivery in ischemic stroke treatment.This paper systematically reviews the structural properties of liposomes,their targeted delivery mechanisms,and their cutting-edge applications in ischemic stroke therapy in the past decade,focusing on the precise accumulation of neuroprotective agents in the ischemic region by surface-modified liposomes through the synergistic strategy of active/passive targeting,especially in piggybacking on the active ingredients of TCM.The paper analyzes in depth the latest advances of modified liposomes in inhibiting neuroinflammation,attenuating ischemia/reperfusion injury,combining with tissue plasminogen activator and biomimetic modification of delivery systems.It aims to provide a new theoretical framework for the precise and individualized treatment of ischemic stroke and to provide a reference for the development of neuroprotective agent delivery systems based on liposome technology.关键词
脂质体/缺血性脑卒中/血脑屏障/组织纤溶酶原激活剂/仿生修饰Key words
liposome/ischaemic stroke/blood-brain barrier/tissue plasminogen activator/biomimetic modification引用本文复制引用
董佳豪,高子涵,韩飞,刘明睿,钱冰露,曹雯萱,刘应蛟..脂质体递送神经保护剂治疗缺血性脑卒中的研究进展[J].中国中药杂志,2025,50(22):6205-6214,10.基金项目
国家自然科学基金项目(82360782) （82360782）
江西省自然科学基金项目(20232BAB206170) （20232BAB206170）
江西省中医药管理局科技计划项目(2021A333) （2021A333）
江西省卫生健康委科技计划项目(202211412) （202211412）
江西中医药大学国家级大学生创新创业训练计划,江西省"十四五"期间药学一流专业建设经费项目(202410412036) （202410412036）
