中国中药杂志2025，Vol.50Issue(22)：6227-6233,7.DOI:10.19540/j.cnki.cjcmm.20250725.701
中医药调控内质网应激防治急性肾损伤、肾间质纤维化、糖尿病肾病研究进展
Prevention and treatment of acute kidney injury,renal interstitial fibrosis,and diabetic kidney disease by regulating endoplasmic reticulum stress with traditional Chinese medicine:a review
摘要
Abstract
As the primary excretory organ responsible for maintaining internal homeostasis,renal dysfunction constitutes the pathological foundation of kidney injury.Renal cells are rich in endoplasmic reticulum(ER)structures,making endoplasmic reticulum stress(ERS)a central mechanism in regulating renal homeostasis.Numerous studies have revealed that aberrant activation of ERS leads to abnormal programmed cell death(PCD)in intrinsic renal cells and is closely associated with the progression of various kidney diseases.Consequently,suppressing ERS has emerged as a promising therapeutic direction in renal disease research.TCM offers wide clinical applicability and demonstrates advantages such as multi-target regulation,efficacy enhancement,and toxicity reduction.Accumulating research demonstrates that TCM ameliorates pathological renal damage by modulating ERS in kidney cells,thereby attenuating disease progression.Based on the regulatory mechanisms of ERS signaling pathways,this review focuses on the mechanistic actions of TCM in modulating ERS and its downstream PCD.It summarizes current evidence on the roles of Chinese herbal monomers and compound formulas for treating acute kidney injury(AKI),renal interstitial fibrosis(RIF),and diabetic kidney disease(DKD)by targeting ERS,aiming to provide novel perspectives for innovative clinical prevention and treatment strategies in renal diseases.关键词
内质网应激/急性肾损伤/肾间质纤维化/糖尿病肾病/中医药Key words
endoplasmic reticulum stress/acute kidney injury/renal interstitial fibrosis/diabetic nephropathy/traditional Chinese medicine引用本文复制引用
黄思雨,王希茜,陈冠廷,陈凯丽,陈旭,张琳琪..中医药调控内质网应激防治急性肾损伤、肾间质纤维化、糖尿病肾病研究进展[J].中国中药杂志,2025,50(22):6227-6233,7.基金项目
国家自然科学基金面上项目(82374381,81973806) （82374381,81973806）
第七批全国名老中医药专家学术经验继承项目(国中医药人教函[2022]76号) （国中医药人教函[2022]76号）
河南省中原千人计划中原名医项目 （）
