中国中药杂志2025，Vol.50Issue(22)：6234-6241,8.DOI:10.19540/j.cnki.cjcmm.20250807.202
线粒体稳态调控血管衰老机制及中医药干预研究进展
Research progress on regulation of mitochondrial homeostasis in vascular aging mechanism and intervention by traditional Chinese medicine
摘要
Abstract
The pathogenesis of vascular aging is complex,and its pathological mechanisms mainly include mitochondrial dysfunction,oxidative stress,epigenetic changes,telomere dysfunction,endothelial dysfunction,and chronic inflammation.However,the pathological mechanism of vascular aging has not yet been fully elucidated.Mitochondria are key organelles regulating metabolism in eukaryotic cells.The imbalance of mitochondrial homeostasis leads to abnormal vascular function.Therefore,regulating mitochondrial homeostasis is considered an important target for the prevention and treatment of vascular aging in the future.Many studies have elucidated that traditional Chinese medicine(TCM)formulas,single herbs,and active components can specifically regulate mitochondrial homeostasis in vascular cells by affecting apoptosis or autophagy,thereby delaying vascular aging.This paper reviewed the role of mitochondrial homeostasis regulation in the pathogenesis of vascular aging from several aspects,including mitochondrial dynamics,mitophagy,mitochondrial biogenesis,and mitochondrial oxidative stress.It also summarized research progress on TCM and its extracts that protect mitochondrial function,maintain mitochondrial homeostasis,and delay vascular aging.These findings provide new ideas and methods for preventing and treating vascular aging with TCM from the perspective of mitochondrial homeostasis.关键词
线粒体稳态/血管衰老/中医药/作用机制Key words
mitochondrial homeostasis/vascular aging/traditional Chinese medicine/mechanism of action引用本文复制引用
钟博宇,陈卓尔,胡琼文,黄欣,姚佳梅,钟广伟,成绍武..线粒体稳态调控血管衰老机制及中医药干预研究进展[J].中国中药杂志,2025,50(22):6234-6241,8.基金项目
国家自然科学基金项目(81673858) （81673858）
湖南省自然科学基金项目(2023JJ30979) （2023JJ30979）
湖南省中医药科研计划项目(C2022032) （C2022032）
湖南省生态环境科研项目(HBKYXM-2023017) （HBKYXM-2023017）
2025年度湖南省大学生创新创业训练计划项目(202510541050) （202510541050）
