中国中药杂志2025，Vol.50Issue(22)：6242-6264,23.DOI:10.19540/j.cnki.cjcmm.20250202.206
贝母属植物天然产物研究进展
Advances in natural products of Fritillaria plants
摘要
Abstract
The traditional Chinese medicine(TCM)known as Beimu,including Fritillariae Cirrhosae Bulbus,Fritillariae Thunbergii Bulbus,Fritillariae Hupehensis Bulbus,Fritillariae Ussuriensis Bulbus,and Fritillariae Pallidiflorae Bulbus,possesses significant medicinal value with a long history of use,has a substantial market demand,and serves as a crucial subject of research.According to Chinese Pharmacopoeia(2020 edition),the dried bulbs of eleven Fritillaria species are the sources of Beimu.The characteristic and active ingredients steroidal alkaloids in Fritillaria species are among the natural products to be investigated earliest globally.These compounds play a pivotal role in the development of natural products and demonstrate a diverse range of pharmacological effects.This review delves into the natural products found in Fritillaria species and their pharmacological properties.Based on literature and the research achievements of the authors' research group,this paper comprehensively summarizes,for the first time,the structural types,physicochemical properties,and spectral characteristics of steroidal alkaloids in Fritillaria species.In-depth analyses reveal that Fritillaria species contain a rich diversity of steroidal alkaloids with varied structural types,and these active ingredients hold promising potential for research on antitussive,anti-pneumonia,and acute lung injury treatment.Additionally,developing effective quality control methods based on steroidal alkaloids is crucial for the development of TCM Beimu and the standardized management of its related cultivated species.关键词
贝母属/中药贝母/天然产物/甾体生物碱/止咳/抗炎Key words
Fritillaria/Beimu/natural products/steroidal alkaloids/antitussive/anti-inflammatory引用本文复制引用
王淑慧,马旭冉,董慧雯,张国武,梁鸿,张庆英,屠鹏飞..贝母属植物天然产物研究进展[J].中国中药杂志,2025,50(22):6242-6264,23.基金项目
国家自然科学基金青年科学基金项目(82304690) （82304690）
中国博士后第17批特别资助项目(2024T170038) （2024T170038）
