中华骨质疏松和骨矿盐疾病杂志2025，Vol.18Issue(5)：554-564,11.DOI:10.3969/j.issn.1674-2591.2025.05.006
TyG指数和TyG-BMI在绝经后骨质疏松症中的筛查价值初探
Analysis of the screening value of the TyG index and TyG-BMI in postmenopausal osteoporosis
摘要
Abstract
Objective To explore the sensitivity and efficacy of the triglyceride-glucose(TyG)index and TyG-body mass index(TyG-BMI)in the screening of postmenopausal osteoporosis(PMOP),and to provide an objective new method for the prevention and early screening of PMOP.Methods Totally 1 032 postmenopausal women who completed bone mineral density test in the Department of Nuclear Medicine,Affiliated Hospital of Nanjing University of Chinese Medi-cine from January 2021 to December 2023 according to the inclusion and exclusion criteria were retrospectively included in the study.The baseline data including age,weight,height,body mass index(BMI),lumbar spine T-score(LS T-score),total hip T-score(TH T-score),femoral neck T-score(FN T-score),fasting blood glucose(FBG),triglyceride(TG),TyG index,TyG-BMI and osteoporosis self-assessment tool for Asians(OSTA)were compared among groups stratified by PMOP.Correlations of the TyG index,TyG-BMI and OSTA with baseline data were analyzed.With OSTA as the reference,the receiver operating characteristic curve(ROC)results of the TyG index and TyG-BMI were analyzed for the overall popu-lation,subgroups stratified by age of 60 years,and subgroups stratified by FBG and TG levels,to determine the sensitivity and efficacy of these indices in screening for PMOP.Results A total of 1 032 postmenopausal women were divided into PMOP group and non-PMOP group.The results demonstrated statistically significant differences between the two groups in terms of age,weight,height,BMI,T-scores at three anatomical sites,TyG-BMI and OSTA(All P＜0.001).Correlation analysis showed that the TyG index,TyG-BMI and OSTA were positively correlated with weight and BMI(All P＜0.001).In the overall cohort and among women aged＜60 years,the TyG index and TyG-BMI showed a positive correlation with age(P＜0.05),while no significant correlation was observed in women aged≥60 years.OSTA was negatively correlated with age and positively correlated with height(Both P＜0.001).Both TyG-BMI and OSTA were positively correlated with T-scores at three anatomical sites(All P＜0.001).The TyG index demonstrated a positive correlation with T-scores at three anatomi-cal sites only in women aged≥60 years(All P＜0.05).The TyG index and TyG-BMI were positively correlated with both FBG and TG(All P＜0.001).In the overall cohort,OSTA was negatively correlated with FBG(P＜0.001)and positively correlated with TG(P＜0.05).After age stratification,no correlation was found between OSTA and FBG,while the positive correlation with TG was only present in women aged≥60 years(P＜0.001).ROC curve analysis indicated that the area un-der the ROC curve(AUC)for TyG-BMI was superior to that of the TyG index but lower than that of OSTA.The AUCs of the TyG index and TyG-BMI for women aged≥60 years were higher than those for women aged＜60 years,while the situation of OSTA was the opposite.The TyG index showed the best specificity in patients with abnormal FBG and/or TG,while TyG-BMI demonstrated better sensitivity.Conclusion TyG-BMI exhibits superior efficacy in screening for PMOP than the TyG index,and can serve as a potential objective indicator for assessing the risk of PMOP.关键词
TyG指数/TyG-BMI/亚洲人骨质疏松症自我筛查工具/骨质疏松症/绝经后女性Key words
TyG index/TyG-BMI/osteoporosis self-assessment tool for Asians(OSTA)/osteoporosis/postm-enopausal women分类
医药卫生引用本文复制引用
杨婧怡,徐道明,张迪,张碧云,柏凌,王尊,张鑫,王胜,刘静..TyG指数和TyG-BMI在绝经后骨质疏松症中的筛查价值初探[J].中华骨质疏松和骨矿盐疾病杂志,2025,18(5):554-564,11.基金项目
江苏省中医药科技发展计划重点项目(ZD202313) （ZD202313）
江苏省中医院重点病种项目(YZJ2404) （YZJ2404）
江苏省中医药特色疗法技术评价(k2025BZ02) （k2025BZ02）
江苏省研究生实践创新计划(SJCX25_0997) （SJCX25_0997）
