中国畜禽种业2025，Vol.21Issue(11)：65-74,10.
基于全基因组测序和关联分析的肉牛重要经济性状的功能基因挖掘及作用研究进展
Research Progress on the Mining and Function of Functional Genes for Important Economic Traits in Cattle Based on Whole Genome Sequencing and Association Analysis
摘要
Abstract
Genetic analysis of important economic traits in beef cattle is the core foundation of molecular breeding.Currently,numerous functional genes regulating important economic traits in beef cattle have been identified based on whole-genome sequencing and association analysis techniques.This article systematically reviews the functional genes and their mechanisms of action for important economic traits such as growth and body type,meat quality,reproductive efficiency,disease resistance,and environmental adaptability in beef cattle.Research indicates that growth and body type are regulated by a multi-gene network,with key genes such as PLAG1 on chromosome 14 enhancing development through the IGF2 pathway and the NCAPG mutation on chromosome 6 promoting myocyte proliferation;meat quality traits are dominated by fat metabolism genes,with FASN on chromosome 19 regulating fatty acid composition and LAMA 4 on chromosome 9 affecting tenderness;reproductive efficiency is associated with the embryo survival pathway,with FOXO1 on chromosome 12 having a stabilizing function for embryo implantation and DGAT1 on chromosome 14 optimizing the nutrient distribution in beef cattle muscles;for disease resistance in beef cattle,high expression of STING1 on chromosome 7 enhances antiviral ability,and SLAMF1 on chromosome 3 is related to the incidence of allergic diseases;environmental adaptability is mediated by stress response genes such as EPAS1 on chromosome 15 for low-oxygen adaptation and the PRLR mutation on chromosome 20 for regulating body heat balance.This review systematically summarizes the functional genes of important economic traits in beef cattle identified through whole-genome sequencing and association analysis techniques,providing molecular targets for precise breeding of economic traits in beef cattle.关键词
肉牛/经济性状/全基因组测序/关联分析/功能基因/影响机制Key words
Beef cattle/Economic traits/Whole-genome sequencing/Association analysis/Functional genes/Mechanism of action分类
农业科技引用本文复制引用
朱治坚,周宇,刁佳宁,卢徐斌,杨章平..基于全基因组测序和关联分析的肉牛重要经济性状的功能基因挖掘及作用研究进展[J].中国畜禽种业,2025,21(11):65-74,10.基金项目
国家重点研发计划(2023YFD1300102-05) （2023YFD1300102-05）
江苏省种业振兴揭榜挂帅项目(JBGS[2021]115) （JBGS[2021]115）
江苏省高校面上项目(24KJB230006). （24KJB230006）
