浙江医学2025，Vol.47Issue(22)：2399-2403,5.DOI:10.12056/j.issn.1006-2785.2025.47.22.2025-448
诺卡菌细胞壁骨架膀胱灌注治疗对中高危非肌层浸润性膀胱癌TURBT术后生存质量的影响
Effect of bladder perfusion with nocardia cell wall skeleton on quality of life in patients with intermediate-and high-risk non-muscle invasive bladder cancer after TURBT
洪钧晖 1应海俊 2张贝贝 3徐志杰 3蒋鹏3
作者信息
- 1. 311500 桐庐县中医院泌尿外科
- 2. 台州市肿瘤医院泌尿外科
- 3. 浙江大学医学院附属第一医院泌尿外科
- 折叠
摘要
Abstract
Objective To investigate the effect of intravesical instillation of nocardia cell wall skeleton(N-CWS)on the quality of life of patients with intermediate-and high-risk non-muscle invasive bladder cancer(NMIBC)after transurethral resection of bladder tumor(TURBT).Methods A retrospective study was conducted on 40 patients with intermediate-and high-risk NMIBC who were intolerant to bacillus calmette-guerin therapy after TURBT and were treated in three hospitals between October 2018 and May 2021,including 16 cases from Tonglu County Hospital of Traditional Chinese Medicine,10 cases from Taizhou Cancer Hospital,and 14 cases from the First Affiliated Hospital of Zhejiang University School of Medicine.Twenty-two patients received intravesical instillation of N-CWS(observation group),and 18 patients received intravesical instillation of mitomycin(control group).The two groups were compared in terms of hematologic parameters,liver and kidney function indices,scores on the specific quality-of-life scale for superficial bladder cancer,incidence of adverse reactions,and 3-year recurrence-free survival rate.Results After 6 months of treatment,the observation group showed higher red blood cell and platelet counts than the control group(both P＜0.05),and lower serum alanine aminotransferase and aspartate aminotransferase levels(both P＜0.05).Scores for urinary symptoms,future concerns,and treatment-related problems were significantly lower in the observation group than in the control group(all P＜0.05).There was no significant difference in the overall incidence of adverse reactions between the two groups(20.0％vs.38.9％,P=0.145).The 3-year recurrence-free survival rate was significantly higher in the observation group than in the control group(94.5％vs.66.7％,P=0.009).Conclusion Intravesical instillation of N-CWS can help prolong survival,improve quality of life,and provide good safety in patients with intermediate-and high-risk NMIBC after TURBT.关键词
红色诺卡菌细胞壁骨架/丝裂霉素/非肌层浸润性膀胱癌/卡介苗芽孢杆菌/膀胱灌注Key words
Nocardia cell wall skeleton/Mitomycin/Non-muscle invasive bladder cancer/Bacillus calmette-guerin/Intravesical administration引用本文复制引用
洪钧晖,应海俊,张贝贝,徐志杰,蒋鹏..诺卡菌细胞壁骨架膀胱灌注治疗对中高危非肌层浸润性膀胱癌TURBT术后生存质量的影响[J].浙江医学,2025,47(22):2399-2403,5.
