中山大学学报（医学科学版）2025，Vol.46Issue(6)：907-919,13.
肾上腺素能与神经母细胞瘤的关系及其靶向治疗的研究进展
Research Advances on the Relationship Between Adrenergic Signaling and Neuroblastoma and its Targeted Therapy
摘要
Abstract
Neuroblastoma(NB),the commonest extracranial solid malignant tumor in children,is an adrenergic-derived neuroendocrine tumor characterized by highly heterogeneous clinical manifestations.Children with high-risk NB exhibit poor prognosis,often experiencing recurrence or metastasis despite intensive intervention.NB cells primarily consist of two subtypes:adrenergic(ADRN)and mesenchymal(MES).The ADRN subtype is associated with differentiation and demonstrates greater sensitivity to differentiation-inducing agents and chemotherapeutic drugs,whereas the MES subtype correlates with invasiveness and chemotherapy resistance.Studies indicate that lineage transition between ADRN and MES subtypes contributes to tumor heterogeneity,potentially triggering chemotherapy resistance or recurrence.Elucidating the molecular mechanisms underlying their interconversion is crucial for overcoming lineage-transition-induced drug resistance and targeting ADRN in high-risk NB treatment.This article comprehensively reviews the role of adrenergic signaling in NB pathogenesis and its intrinsic molecular regulatory mechanisms while summarizing recent advances in ADRN-targeted strategies for NB clinical diagnosis and treatment,with an aim to provide a theoretical basis for future clinical management and prevention of NB.关键词
神经母细胞瘤/肾上腺素能/高危/核心调控环路/靶向治疗Key words
neuroblastoma/adrenergic/high risk/core regulatory circuitry/targeted therapy分类
医药卫生引用本文复制引用
杨洋,杨霞..肾上腺素能与神经母细胞瘤的关系及其靶向治疗的研究进展[J].中山大学学报（医学科学版）,2025,46(6):907-919,13.基金项目
国家自然科学基金(82273116) （82273116）
广东省自然科学基金(2024A1515010149) （2024A1515010149）
