中山大学学报（医学科学版）2025，Vol.46Issue(6)：920-934,15.
非编码RNA调控细胞程序性死亡影响慢性肾脏病的研究进展
Advances on the Regulation of Programmed Cell Death by Non-coding RNAs in Chronic Kidney Disease
摘要
Abstract
Chronic kidney disease(CKD)is a common disease with high morbidity and mortality.Increasing evidence has indicated that programmed cell death(PCD)plays a significant role in the pathogenesis and progression of CKD.Non-coding RNA(ncRNA),defined as a category of RNA that lacks coding potential,has emerged as a pivotal regulator of gene expression.This regulatory function of ncRNA extends to various biological processes,including PCD.This paper reviews the recent advances on the involvement of ncRNAs in the regulation of apoptosis,autophagy,pyroptosis,ferroptosis,necroptosis,and PANoptosis in CKD.It explores the crosstalk between different pathways and categorizes therapeutic strategies targeting ncRNA regulation of PCD into three main areas:the active ingredients of traditional Chinese medicine,tissue engineering technologies,and drugs.The objective of this study is to identify novel therapeutic targets and strategies for clinical treatment.关键词
慢性肾脏病/非编码RNA/凋亡/自噬/焦亡/铁死亡Key words
chronic kidney disease/non-coding RNA/apoptosis/autophagy/pyroptosis/ferroptosis分类
医药卫生引用本文复制引用
盛道宇,丁樱..非编码RNA调控细胞程序性死亡影响慢性肾脏病的研究进展[J].中山大学学报（医学科学版）,2025,46(6):920-934,15.基金项目
国家自然科学基金(82205187) （82205187）
国医大师工作室建设项目(国中医药人教发[2022]245号,丁樱国医大师传承工作室) （国中医药人教发[2022]245号,丁樱国医大师传承工作室）
2023年度河南省医学科技攻关计划项目联合共建项目(LHGJ20230684) （LHGJ20230684）
