中山大学学报（医学科学版）2025，Vol.46Issue(6)：935-944,10.
线粒体自噬和能量代谢在消化道肿瘤中的研究进展
Research Progress on Mitophagy and Energy Metabolism in Digestive Tract Tumors
摘要
Abstract
Mitophagy is an evolutionarily highly conserved selective autophagy process that maintains cellular homeostasis and mitochondrial quality control by specifically recognizing and removing damaged or superfluous mitochondria.During tumorigenesis,mitophagy eliminates damaged mitochondria and reduces the accumulation of reactive oxygen species(ROS),thereby helping to sustain cellular homeostasis.Energy metabolism refers to the core biological process through which cells convert chemical energy from nutrients into adenosine triphosphate(ATP)via biochemical pathways such as glycolysis and oxidative phosphorylation,providing energy for cellular activities.While research on gastrointestinal tumors is advancing rapidly,a major bottleneck lies in their complex metabolic adaptations and therapeutic resistance.Targeting the interplay between mitophagy and energy metabolism has emerged as a promising therapeutic strategy for this disease.Current research on mitophagy and energy metabolism in gastrointestinal tumors,including the molecular mechanisms of their bidirectional regulatory network and applications in targeted therapies,remains to be systematically elucidated.Therefore,this review summarizes the implications of the mitophagy-energy metabolism interplay in gastrointestinal tumors,with the aim of providing insights for future research.关键词
线粒体自噬/能量代谢重编程/消化道肿瘤/肿瘤微环境/靶向治疗/综述Key words
mitophagy/energy metabolism reprogramming/gastrointestinal tumors/tumor microenvironment/targeted therapy/review分类
医药卫生引用本文复制引用
赵康杓,王小平..线粒体自噬和能量代谢在消化道肿瘤中的研究进展[J].中山大学学报（医学科学版）,2025,46(6):935-944,10.基金项目
国家自然科学基金(82460515) （82460515）
陕西省自然科学基础研究计划项目(2025JC-YBMS-1088) （2025JC-YBMS-1088）
中央引导地方科技发展资金项目(LSKJ202447) （LSKJ202447）
咸阳市科技计划重点研发项目(L2024-ZDYF-SF-0025) （L2024-ZDYF-SF-0025）
