中山大学学报（医学科学版）2025，Vol.46Issue(6)：964-972,9.
程序性细胞死亡在肺缺血再灌注损伤中的研究进展
Research Advancements on Programmed Cell Death in Lung Ischemia Reperfusion Injury
摘要
Abstract
Lung transplantation(LTx)is the only effective curative treatment for end-stage lung disease(ESLD),applicable to patients with advanced lung diseases who do not respond to medical and other surgical management,and can significantly improve the prognosis.However,LTx still faces many challenges,such as ischemia-reperfusion injury(IRI)and low long-term survival.Improving lung IRI is of great significance for the recovery of lung function and the prognosis of patients after transplantation.Lung IRI is a response to tissue damage and inflammation that worsens when the blood supply to the lung tissue is restored(reperfusion)after it has undergone a disruption of blood flow(ischemia).IRI is an important pathophysiological basis for primary graft dysfunction(PGD),and its injury mechanisms are complex and diverse,involving the activation of multiple cell deaths.Programmed cell death(PCD)is a highly ordered process of cell self-extinction regulated by genes,mainly including apoptosis,necroptosis,autophagy,ferroptosis,pyroptosis and cuproptosis,which are of great physiological significance for maintaining biological development,homeostasis and immune defense.Recent studies have shown that the activation of multiple PCDs is closely related to the occurrence and development of lung IRI.PCD is widely involved in lung IRI through different molecular mechanisms,but its specific regulatory mechanism has not been fully elucidated.This article systematically reviews the latest progress of various types of PCD in lung IRI,analyzes the molecular mechanism and interaction of PCD in lung IRI,and explores their potential as therapeutic targets,aiming to provide new insights for the development of clinical lung protection strategies.关键词
肺缺血再灌注损伤/凋亡/坏死性凋亡/自噬/铁死亡/焦亡/铜死亡Key words
lung ischemia reperfusion injury/apoptosis/necroptosis/autophagy/ferroptosis/pyroptosis/cuproptosis分类
医药卫生引用本文复制引用
虞燕青,孙煦勇..程序性细胞死亡在肺缺血再灌注损伤中的研究进展[J].中山大学学报（医学科学版）,2025,46(6):964-972,9.基金项目
广西重点研发计划(桂科AB24010059) （桂科AB24010059）
广西自然科学基金区域高发疾病研究联合专项(2024GXNSFAA010454) （2024GXNSFAA010454）
