中山大学学报（医学科学版）2025，Vol.46Issue(6)：995-1005,11.
1990-2021年中国归因于高低密度脂蛋白胆固醇的心血管疾病负担分析
Analysis of the Cardiovascular Disease Burden Attributable to High Low-Density Lipoprotein Cholesterol in China from 1990 to 2021
摘要
Abstract
[Objective]Cardiovascular diseases pose a major public health challenge in China.The burden of cardiovascular disease associated with high low-density lipoprotein cholesterol(LDL-C)has increased steadily nationwide.A comprehensive analysis of secular trends in cardiovascular disease burden and its determinants is crucial for developing targeted interventions and evidence-based health policies.[Methods]Based on data from the Global Burden of Disease Study 2021,we analyzed the trends in deaths,disability-adjusted life years(DALYs),age-standardized mortality rates(ASMR),and age-standardized DALY rates(ASDR)of cardiovascular diseases attributable to high LDL-C in China from 1990 to 2021 using Joinpoint regression analysis.An age-period-cohort model was applied to assess the contributions of age,period,and cohort effects to changes in the cardiovascular disease burden attributable to high LDL-C.Projections of the high LDL-C-attributable cardiovascular disease burden in China from 2022 to 2030 were generated using a Bayesian age-period-cohort model.[Results]Between 1990 and 2021,China saw a substantial rise in both deaths and disability-adjusted life years(DALYs)from cardiovascular disease linked to high LDL-C.Joinpoint regression revealed key turning points in this trend:an overall increase continued until 2004,after which the burden began to fall starting in 2011.Throughout this period,age-standardized mortality and DALY rates were consistently higher in males than in females.Age-period-cohort analysis further indicated that mortality and DALY rates due to high LDL-C increased almost exponentially with age,while period and cohort risks generally decreased over time.Projections suggest a continued decline in age-standardized mortality rates from LDL-C-related cardiovascular disease for both Chinese men and women by 2030.[Conclusion]Rapid population growth and accelerated ageing in China emerge as primary drivers of the escalating cardiovascular diseases burden linked to elevated LDL-C.The burden of cardiovascular diseases is higher in men compared to women.By 2030,the burden of cardiovascular disease caused by high LDL-C in China will remain severe.These findings underscore the critical need for gender-specific screening protocols,age-tailored interventions,and personalized management frameworks to mitigate this public health challenge.关键词
疾病负担/心血管疾病/低密度脂蛋白胆固醇/Joinpoint 回归模型/年龄-时期-队列模型Key words
disease burden/cardiovascular disease/low-density lipoprotein cholesterol/Joinpoint regression/age-period-cohort analysis分类
医药卫生引用本文复制引用
龙云骧,黄柔鸳,王明亮,刘一鎏,莫日柱,龙航,王晓武..1990-2021年中国归因于高低密度脂蛋白胆固醇的心血管疾病负担分析[J].中山大学学报（医学科学版）,2025,46(6):995-1005,11.基金项目
国家自然科学基金(82400470) （82400470）
