中国现代医生2025，Vol.63Issue(32)：12-16,5.DOI:10.3969/j.issn.1673-9701.2025.32.004
脓毒症患儿早期持续血液净化预测模型构建
Construction of predictive model for continuous renal replacement therapy in early stage of sepsis children
摘要
Abstract
Objective To screen the predictors of early initiation of continuous renal replacement therapy(CRRT)in children with sepsis and construct a linear model,based on LASSO regression analysis.Methods A total of 55 children diagnosed with sepsis at Jiangmen Maternity and Child Health Care Hospital from April 2023 to February 2025.They were divided into CRRT group(n=17)and non-CRRT group(n=38)based on CRRT treatment usage.Using LASSO regression screening,predictive factors were identified and a Logistic regression model was established.The model's performance was evaluated using receiver operating characteristic(ROC)curve and calibration curve.Results There were significant differences in age,respiratory rate,body temperature,and mechanical ventilation between two groups(P＜0.05).Through LASSO regression analysis,four independent predictors of respiratory rate,body temperature,blood glucose,and C-reactive protein were identified.The constructed model demonstrated an area under the ROC curve of 0.94(95％CI:0.87-1.00),indicating good calibration accuracy.Conclusion The column line model based on body temperature,respiratory rate,blood glucose and C-reactive protein can effectively predict the need for early initiation of CRRT in sepsis children.关键词
脓毒症/持续血液净化/LASSO回归/预测模型Key words
Sepsis/Continuous renal replacement therapy/LASSO regression/Prediction model分类
医药卫生引用本文复制引用
叶鑫,蔡启茵,黄嘉丽,刘琴,陈光辉,覃朝富,梁婷..脓毒症患儿早期持续血液净化预测模型构建[J].中国现代医生,2025,63(32):12-16,5.基金项目
广东省江门市科技计划项目(2023YL04006) （2023YL04006）
