中国现代医生2025，Vol.63Issue(32)：22-27,6.DOI:10.3969/j.issn.1673-9701.2025.32.006
哮喘相关性肺炎与心力衰竭因果关系的双向两样本孟德尔随机化研究
Two-sample Mendelian randomization study of the causal relationship between asthma-related pneumonia and heart failure
摘要
Abstract
Objectives To explore the causal relationship between asthma-related pneumonia and heart failure(HF)by using two-sample Mendelian randomization(MR)analysis.Methods The causal relationship between asthma-related pneumonia and HF were systematically evaluated through two-sample MR analysis based on publicly available Genome-Wide Association Study data.Inverse variance weighted(IVW),MR-Egger,weighted median,weighted mode,and simple mode methods were used.Different models were used to analyze sensitivity.Testing approaches were conducted to assess the robustness of the results.Results IVW analysis results showed that there was a causal relationship between asthma-related pneumonia and HF risk(OR=1.113,95％CI:1.027-1.206,P=0.009).HF was not found to have a causal effect on asthma-related pneumonia risk based on IVW analysis(OR=1.018,95％CI:0.780-1.328,P=0.893).The variance used in all MR analyses showed no heterogeneity or horizontal pleiotropy.The leave-one-out analysis revealed that no single nucleotide polymorphism disproportionately influenced the results,further confirming the credibility of the bidirectional MR findings.Conclusion This study established a causal relationship between asthma-related pneumonia and HF risk.No clear causal relationship between HF and asthma-related pneumonia risk was found.关键词
哮喘相关性肺炎/心力衰竭/孟德尔随机化分析/因果关系Key words
Asthma-related pneumonia/Heart failure/Mendelian randomization analysis/Causal relationship分类
医药卫生引用本文复制引用
苏照海,曹竣,吴诗蓉,杨荣源,刘擎,刘青艳..哮喘相关性肺炎与心力衰竭因果关系的双向两样本孟德尔随机化研究[J].中国现代医生,2025,63(32):22-27,6.基金项目
广东省珠海市社会发展领域科技计划重点项目(2320004000286) （2320004000286）
