摘要
Abstract
Objective:To analyze the influence of massive blood transfusion in trauma patients on the coagulation function level and inflammatory factor indicators.Method:A total of 103 trauma patients admitted to the Third People's Hospital of Jingzhou City from January 2022 to December 2024 were selected as the research subjects for retrospective analysis.According to the different blood transfusion volumes,they were divided into the massive blood transfusion group(n=53)and the non-massive blood transfusion group(n=50).The coagulation function levels,inflammatory factor indicators,the incidence of post-traumatic multiple organ dysfunction syndrome(MODS),and the mortality rate were compared between the two groups.Result:At T0,there was no statistically significant difference in fibrinogen(Fib),prothrombin time(PT),activated partial thromboplastin time(APTT),and thrombin time(TT)between the two groups(P>0.05).At T1,PT,APTT,and TT in both groups increased,and those in the massive blood transfusion group were higher.Fib in both groups decreased,and those in the massive blood transfusion group were lower.The difference was statistically significant(P<0.05).Compared with T1,at T2,Fib in both groups increased,but it was higher in the non-massive blood transfusion group.PT,APTT and TT in both groups decreased,but they were lower in the non-massive blood transfusion group,and the difference was not statistically significant(P>0.05).At T0,there was no statistically significant difference in tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),and interleukin-6(IL-6)between the two groups(P>0.05).At T1 TNF-α,CRP,and IL-6 increased in both groups,and were even higher in the group with massive blood transfusion.There was a statistically significant difference in TNF-α and CRP(P<0.05).Compared with T1,in T2,TNF-α,CRP and IL-6 in both groups decreased,but they were lower in the non-massive blood transfusion group,and the difference was not statistically significant(P>0.05).The incidence and mortality of multiple organ dysfunction syndrome in the observation group were both higher than those in the control group,but the difference was not statistically significant(P>0.05).Conclusion:Although massive blood transfusion treatment for trauma patients can restore blood volume in a short period of time,it has a significant impact on coagulation function and the body's inflammatory response in the short term.Therefore,it is necessary to enhance the monitoring intensity at this stage to prevent the occurrence of unexpected events.关键词
创伤/大量输血/凝血功能/炎症因子Key words
Trauma/Massive transfusion/Coagulation function/Inflammatory markers
