中国中西医结合杂志2025，Vol.45Issue(11)：1325-1330,6.DOI:10.7661/j.cjim.20251014.023
通督调神电针调节脑类淋巴功能改善失眠症沿血管周围间隙弥散张量成像
Tongdu Tiaoshen Electroacupuncture Improves Insomnia Patients' Diffusion Tensor Imaging Along Perivascular Space by Regulating Glymphatic Function
摘要
Abstract
Objective To investigate the brain mechanisms of Tongdu Tiaoshen electroacupuncture in treating insomnia disorder(ID)by assessing the Diffusion Tensor Imaging along the Perivascular Space(DTI-ALPS)index.Methods Twenty ID patients received Tongdu Tiaoshen electroacupuncture at Baihui(GV20),Yintang(GV29),bilateral Shenmen(HT7),and Sanyinjiao(SP6),with electrical stimulation(30 min/session,every other day,12 sessions total).The Pittsburgh Sleep Quality Index(PSQI),Hyperarousal Scale(HAS),and portable polysomnography(PPSG)parameters were evaluated,and DTI scans were performed to calculate the ALPS index before and after treatment.A demographically matched healthy control(HC)group was recruited to establish baseline data.Comparisons were made between pre-and post-treatment outcomes in the ID group,as well as for ALPS differences between the ID and HC groups.Stratified and correlation analyses were also conducted.Results After treatment,ID patients showed significant reductions in PSQI and HAS scores(P＜0.01),increased total sleep time(TST),sleep efficiency(SE),and NREM 3％(P＜0.05),and decreased sleep latency(SL)and wake after sleep onset(WASO)(P＜0.05).Baseline ALPS values were lower in the ID group than in the HC group(P＜0.05).Although the post-treatment change in ALPS was not statistically significant,a slight increase was observed(A=0.04).Patients with high baseline ALPS showed significant improvement after treatment(P＜0.05).ALPS values were positively correlated with SE(r=0.394)and negatively correlated with WASO(r=-0.409).Conclusions Tongdu Tiaoshen electroacupuncture may improve ALPS and sleep parameters in ID patients by modulating brain glymphatic system,providing multimodal neuroimaging evidence for its central mechanism of action.关键词
失眠症/通督调神/电针/类淋巴系统/便携式多导睡眠监测/沿血管周围间隙弥散张量成像Key words
insomnia disorder/Tongdu Tiaoshen/electroacupuncture/glymphatic system/portable polysomnography/diffusion tensor imaging along the perivascular space引用本文复制引用
李沐风,吴文忠,刘成勇,王璐瑶,秦珊,夏建伟,万青云,王晓秋,王晓骁,蒋皆恢..通督调神电针调节脑类淋巴功能改善失眠症沿血管周围间隙弥散张量成像[J].中国中西医结合杂志,2025,45(11):1325-1330,6.基金项目
国家自然科学基金资助项目(No.82274631,No.82205252,No.82305384,No.82405587) （No.82274631,No.82205252,No.82305384,No.82405587）
江苏省中医药领军人才培养项目(No.SLJ0313) （No.SLJ0313）
江苏省重点研发计划社会发展项目(No.BE2023793) （No.BE2023793）
南京中医药大学针药结合教育部重点实验室主任基金项目(No.AML202301) （No.AML202301）
国家中医临床研究基地开放课题面上项目(No.JD2022SZXMS01) （No.JD2022SZXMS01）
江苏省中医药科技发展计划(No.MS2023026) （No.MS2023026）
