中国现代中药2025，Vol.27Issue(11)：2013-2017,5.DOI:10.13313/j.issn.1673-4890.20250103002
中药材中禁用农药克百威便携式质谱检测方法的建立
Development of A Portable Mass Spectrometry Method for Determination of the Banned Pesticide Carbofuran in Chinese Medicinal Materials
摘要
Abstract
Objective:To establish a rapid detection method for carbofuran in Chinese medicinal materials(CMM)using portable mass spectrometry.Methods:Notoginseng Radix et Rhizoma and Lycii Fructus were used as the research objects.The samples were subjected to direct extraction,and the extracts were purified using hydrophilic-lipophilic balance(HLB)solid-phase extraction columns.Carbofuran in the samples was analyzed by portable mass spectrometry in the positive ion mode.Results:Carbofuran showed good linearity(r>0.99)with peak area within the concentration range of 0.25-10.00 mg·kg-1.The limits of detection(LOD)and quantification(LOQ)for carbofuran in Notoginseng Radix et Rhizoma and Lycii Fructus were 0.10 mg·kg-1 and 0.25 mg·kg-1,respectively.The recovery rate of carbofuran in Notoginseng Radix et Rhizoma was 94%at the spiked level of 2.0 mg·kg-1,with a relative standard deviation(RSD)of 18%(n=8).The recovery rate of carbofuran in Lycii Fructus was 78%at the spiked level of 1.00 mg·kg-1,with the RSD of 17%(n=8).These results meet the requirements of trace analysis.Conclusion:The established method is rapid,accurate,and operable,and can be applied to the daily rapid screening of carbofuran in Notoginseng Radix et Rhizoma and Lycii Fructus.This approach provides a technical reference for the development of rapid detection methods for other pesticides in CMM.关键词
便携式质谱/中药材/克百威/农药残留Key words
portable mass spectrometry/Chinese medicinal materials/carbofuran/pesticide residue分类
医药卫生引用本文复制引用
王莹,周婷婷,刘芫汐,李海亮,左红芬,王淑红,金红宇..中药材中禁用农药克百威便携式质谱检测方法的建立[J].中国现代中药,2025,27(11):2013-2017,5.基金项目
国家重点研发计划项目(2023YFC3504103) （2023YFC3504103）
国家药品监督管理局药品监管科学全国重点实验室第一批开放课题(2023SKLDRS0103) （2023SKLDRS0103）
