中医肿瘤学杂志2025，Vol.7Issue(6)：19-27,9.DOI:10.19811/j.cnki.ISSN2096-6628.2025.11.003
瘀血阻抑正气形成免疫抑制性肿瘤微环境的病机探讨
Discussion on the Pathogenesis of Blood Stasis Inhibiting Healthy Qi and Forming Immunosuppressive Tumor Microenvironment
摘要
Abstract
Blood stasis is the core pathogenesis and syndrome in the formation of abdominal masses.Huangdi Neijing emphasizes exogenous pathogens,posing that cold congeals blood and blood stasis accumulates to form abdominal masses.Zhang Zhongjing advocated that chronic strain injuries generated blood stasis leading to abdominal masses.Zhu Danxi innovatively proposed the theory of"phlegm-blood stasis co-aggregation"forming nest-like lesions.The"protracted illness penetrates collaterals"theory remains pivotal in oncology therapy today.Qi-blood interaction within vessels is fundamental.Qi stagnation due to blood stasis impedes healthy qi,enabling pathogenic toxins to linger and form abdominal masses.This also underlies cancer metastasis.Tortuous and leaky vasculature with hypercoagulability disrupts the infiltration of immune cells with tumor-killing effects.T-cell repulsion within the tumor microenvironment(TME)leads to the failure of healthy qi.Dysfunction of T cells and natural killer(NK)cells,which constitute the anti-tumor healthy qi,induces abnormal vascular development,and exacerbates blood stasis.Within abdominal masses,blood stasis and deficiency of healthy qi interact pathogenically.Deficiency of healthy qi is the prerequisite promoting abdominal masses formation.Treating disease requires targeting the root cause.Therefore,since the Song Dynasty,blood activating and stasis resolving herbs have gradually become mainstream for abdominal masses.Resolving blood stasis is equivalent to nourishing healthy qi,and nourishing healthy qi will naturally dissipate accumulations.关键词
瘀血/正虚/癥瘕积聚/活血化瘀/免疫抑制性微环境Key words
blood stasis/deficiency of healthy qi/abdominal mass/activating blood and resolving stasis/immunosuppressive tumor microenvironment分类
医药卫生引用本文复制引用
严心怡,姜谷蓉,郑烨韵,韩钦芮,陈修平,孙学刚..瘀血阻抑正气形成免疫抑制性肿瘤微环境的病机探讨[J].中医肿瘤学杂志,2025,7(6):19-27,9.基金项目
国家重点研发计划"中医药现代化"重点专项(编号:2023YFC3502802) （编号:2023YFC3502802）
国家自然科学基金面上项目(编号:82274387) （编号:82274387）
国家自然科学基金面上项目(编号:82574892) （编号:82574892）
广东省基础与应用基础研究基金项目(编号:2022A1515011147). （编号:2022A1515011147）
