中医肿瘤学杂志2025，Vol.7Issue(6)：77-82,6.DOI:10.19811/j.cnki.ISSN2096-6628.2025.11.010
利咽败毒汤联合氧喷治疗鼻咽癌患者放射性口咽炎的疗效观察
Observation on the Efficacy of Liyan Baidu Decoction Combined with Oxygen Spray in the Treatment of Radiation-Induced Oropharyngitis in Nasopharyngeal Carcinoma Patients
摘要
Abstract
Objective To observe the efficacy of Liyan Baidu Decoction combined with oxygen spray in nasopharyngeal carcinoma(NPC)patients with radiation-induced oropharyngitis.Methods A total of 100 NPC patients with radiation-induced oropharyngitis treated in Cangzhou Hospital of Integrated Traditional Chinese and Western Medicine in Hebei Province from March 2021 to May 2024 were selected and randomly divided into a treatment group of 50 cases and a control group of 50 cases.The treatment group was treated with Liyan Baidu Decoction combined with oxygen spray,while the control group was treated with oral administration of Kangfuxin Liquid.The time of oral mucosal injury occurrence,the corresponding cumulative radiation dose at the time of reaction onset,grading of oral mucosal reaction,degree of salivary gland injury,and changes in karnofsky performance status(KPS)score before and after treatment were compared between the two groups.Results Compared with the control group,the treatment group had a later onset time of oral mucosal reaction(P＜0.05)and a higher cumulative radiation dose at the time of reaction occurrence(P＜0.05).When the radiation dose reached 50Gy and at the end of radiotherapy,there were statistically significant differences in the grading of oral mucosal reaction(P＜0.05)and the degree of salivary gland injury(P＜0.05)between the two groups.The KPS scores of both groups were mostly improved after treatment,but the quality of life in the Liyan Baidu Decoction group was higher than that in the control group,with a statistically significant difference(P＜0.05).Conclusion Liyan Baidu Decoction combined with oxygen spray can delay the initial occurrence time of acute radiation-induced oral mucosal reaction in patients with nasopharyngeal carcinoma,effectively alleviate the degrees of radiation-induced oral mucosal injury and salivary gland injury,and improve the quality of life.关键词
放射性口咽炎/利咽败毒汤/氧喷/临床观察Key words
radiation-induced oropharyngitis/Liyan Baidu Decoction/oxygen spray/clinical observation分类
医药卫生引用本文复制引用
齐子威,胡秀茹..利咽败毒汤联合氧喷治疗鼻咽癌患者放射性口咽炎的疗效观察[J].中医肿瘤学杂志,2025,7(6):77-82,6.基金项目
河北省中医药管理局科技计划项目(编号:20191282). （编号:20191282）
