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Synthetic genomics-based generation of the tick-borne encephalitis virus Siberian subtype prototype strain and E51K-attenuated variant for vaccine development and antiviral screening

Tolganay Kulatay Elena Sedova Alexander Shevtsov Gulzat Zauatbayeva Bakytkali Ingirbay Viktoriya Keyer Zhanar Shakhmanova Maral Zhumabekova Yergali Abduraimov Aralbek Rsaliyev Nurgul Sikhayeva Irina Kozlova Mikhail Zaripov Alexandr V.Shustov

Virologica Sinica2025，Vol.40Issue(5)：P.812-821,10.

Virologica Sinica2025，Vol.40Issue(5)：P.812-821,10.DOI:10.1016/j.virs.2025.09.010

Synthetic genomics-based generation of the tick-borne encephalitis virus Siberian subtype prototype strain and E51K-attenuated variant for vaccine development and antiviral screening

Tolganay Kulatay ¹Elena Sedova ¹Alexander Shevtsov ¹Gulzat Zauatbayeva ¹Bakytkali Ingirbay ¹Viktoriya Keyer ¹Zhanar Shakhmanova ¹Maral Zhumabekova ¹Yergali Abduraimov ²Aralbek Rsaliyev ²Nurgul Sikhayeva ²Irina Kozlova ³Mikhail Zaripov ⁴Alexandr V.Shustov¹

作者信息

1. National Center for Biotechnology,Astana,010000,Kazakhstan
2. National Holding QazBioPharm,Astana,010000,Kazakhstan
3. Federal State Budgetary Scientific Institution“ScientificСentre for Family Health and Human Reproduction Problems”,Irkutsk,664003,Russian Federation
4. Institute of Theoretical and Experimental Biophysics,Pushchino,142290,Russian Federation
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摘要

关键词

Tick-borne encephalitis virus(TBEV)/Infectious clone/Virus adaptation/Heparan sulfate/Favipiravir/Antiviral activity

分类

医药卫生

引用本文复制引用

Tolganay Kulatay,Elena Sedova,Alexander Shevtsov,Gulzat Zauatbayeva,Bakytkali Ingirbay,Viktoriya Keyer,Zhanar Shakhmanova,Maral Zhumabekova,Yergali Abduraimov,Aralbek Rsaliyev,Nurgul Sikhayeva,Irina Kozlova,Mikhail Zaripov,Alexandr V.Shustov..Synthetic genomics-based generation of the tick-borne encephalitis virus Siberian subtype prototype strain and E51K-attenuated variant for vaccine development and antiviral screening[J].Virologica Sinica,2025,40(5):P.812-821,10.

基金项目

supported by funds from the scientific and technical program BR218004/0223“Improving measures to ensure biological safety in Kazakhstan:counteracting dangerous and especially dangerous infections”.Part of this work carried out in Russian Federation was supported by internal grant funding from the Scientific Centre for Family Health and Human Reproduction Problems:grant number 121022500179-0.Title:“Molecular,Organismal,and Population Patterns of the Epidemic Process of Anthropozoonotic and Transmissible Infections in the Territory of Northern Asia and Adjacent Areas". （）

Virologica Sinica

ISSN：1674-0769

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