首页|期刊导航|Virologica Sinica|A safe and broad-spectrum SARS-CoV-2 mRNA vaccine with a new delivery system for in-situ expression

A safe and broad-spectrum SARS-CoV-2 mRNA vaccine with a new delivery system for in-situ expression

Weiyi Yu Xianying Chen Qiubing Chen Peixuan Chen Naizhang Liu Yingjian Li Xue Tan Qiuhan Zhang Yan Rao Ming Guo Zhixiang Huang Xin Wang Zhen ZhangWenjie Xiang Yuzhen Zhang Qianyun Liu Hao Yin Li Zhou Yu Chen Ke Lan

Virologica Sinica2025，Vol.40Issue(5)：P.793-803,11.

Virologica Sinica2025，Vol.40Issue(5)：P.793-803,11.DOI:10.1016/j.virs.2025.09.001

A safe and broad-spectrum SARS-CoV-2 mRNA vaccine with a new delivery system for in-situ expression

Weiyi Yu ¹Xianying Chen ²Qiubing Chen ³Peixuan Chen ¹Naizhang Liu ¹Yingjian Li ¹Xue Tan ¹Qiuhan Zhang ⁴Yan Rao ²Ming Guo ¹Zhixiang Huang ²Xin Wang ¹Zhen ZhangWenjie Xiang ¹Yuzhen Zhang ¹Qianyun Liu ¹Hao Yin ⁵Li Zhou ²Yu Chen ¹Ke Lan⁶

作者信息

1. State Key Laboratory of Virology and Biosafety,RNA Institute,College of Life Sciences,Wuhan University,Wuhan,430072,China
2. Institute for Vaccine Research at Animal Bio-safety Level III Laboratory,Wuhan University,Wuhan,430071,China
3. Departments of Urology and Laboratory Medicine,Frontier Science Center for Immunology and Metabolism,Medical Research Institute,Zhongnan Hospital of Wuhan University,Wuhan University,Wuhan,430071,China
4. Department of Infectious Diseases,Frontier Science Center for Immunology and Metabolism,Medical Research Institute,Zhongnan Hospital of Wuhan University,Wuhan University,Wuhan 430071,China
5. Departments of Urology and Laboratory Medicine,Frontier Science Center for Immunology and Metabolism,Medical Research Institute,Zhongnan Hospital of Wuhan University,Wuhan University,Wuhan,430071,China Taikang Center for Life and Medical Sciences,Wuhan University,Wuhan 430071,China
6. State Key Laboratory of Virology and Biosafety,RNA Institute,College of Life Sciences,Wuhan University,Wuhan,430072,China Institute for Vaccine Research at Animal Bio-safety Level III Laboratory,Wuhan University,Wuhan,430071,China Department of Infectious Diseases,Frontier Science Center for Immunology and Metabolism,Medical Research Institute,Zhongnan Hospital of Wuhan University,Wuhan University,Wuhan 430071,China Taikang Center for Life and Medical Sciences,Wuhan University,Wuhan 430071,China
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摘要

关键词

SARS-CoV-2/mRNA vaccine/Lipid nanoparticles

分类

医药卫生

引用本文复制引用

Weiyi Yu,Xianying Chen,Qiubing Chen,Peixuan Chen,Naizhang Liu,Yingjian Li,Xue Tan,Qiuhan Zhang,Yan Rao,Ming Guo,Zhixiang Huang,Xin Wang,Zhen ZhangWenjie Xiang,Yuzhen Zhang,Qianyun Liu,Hao Yin,Li Zhou,Yu Chen,Ke Lan..A safe and broad-spectrum SARS-CoV-2 mRNA vaccine with a new delivery system for in-situ expression[J].Virologica Sinica,2025,40(5):P.793-803,11.

基金项目

supported by the National Key R&D Program of China(2021YFF0702000 to Y.Chen,2021YFC2300700 to L.Zhou) （2021YFF0702000 to Y.Chen,2021YFC2300700 to L.Zhou）

the National Natural Science Foundation of China(grants 82341061,82172243 and 82372223 to Y.Chen) （grants 82341061,82172243 and 82372223 to Y.Chen）

the Fundamental Research Funds for the Central Universities(2042022dx0003 to Y.Chen) （2042022dx0003 to Y.Chen）

the Hubei Provincial Natural Science Foundation(2023AFB201 to Z.Zhang,and 2024AFB906 to L.Zhou.) （2023AFB201 to Z.Zhang,and 2024AFB906 to L.Zhou.）

the China Postdoctoral Science Foundation(2023M732705 to Q.Liu). （2023M732705 to Q.Liu）

Virologica Sinica

ISSN：1674-0769

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