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Investigation on the Anti-Cancer Effects of HER2-Targeted CAR-T Cells Engineered Using the PiggyBac Transposon System

Tian-Tian Li Ming-Yao Meng Zheng Yu Yang-Fan Guo Yi-Yi Zhao Hui Gao Li-Li Yang Li-Rong Yang Meng-Yuan Chu Shan He Yuan Liu Xiao-Dan Wang Wen-Ju Wang Zong-Liu Hou Li-Wei Liao Lin Li

Oncology Research2025，Vol.33Issue(11)：P.3447-3467,21.

Oncology Research2025，Vol.33Issue(11)：P.3447-3467,21.DOI:10.32604/or.2025.065394

Investigation on the Anti-Cancer Effects of HER2-Targeted CAR-T Cells Engineered Using the PiggyBac Transposon System

Tian-Tian Li ¹Ming-Yao Meng ²Zheng Yu ³Yang-Fan Guo ²Yi-Yi Zhao ²Hui Gao ²Li-Li Yang ¹Li-Rong Yang ¹Meng-Yuan Chu ¹Shan He ²Yuan Liu ²Xiao-Dan Wang ²Wen-Ju Wang ²Zong-Liu Hou ²Li-Wei Liao ²Lin Li²

作者信息

1. Central Laboratory,Yan’an Hospital Affiliated to Kunming Medical University,Kunming,650051,China Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province,Yan’an Hospital Affiliated to Kunming Medical University,Kunming,650051,China Graduate School,Kunming Medical University,Kunming,650050,China
2. Central Laboratory,Yan’an Hospital Affiliated to Kunming Medical University,Kunming,650051,China Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province,Yan’an Hospital Affiliated to Kunming Medical University,Kunming,650051,China Yunnan Cell Biology and Clinical Translation Research Center,Yan’an Hospital Affiliated to Kunming Medical University,Kunming,650051,China
3. School of Life Science and Technology,ShanghaiTech University,Shanghai,201210,China
折叠

摘要

关键词

Chimeric antigen receptor T/human endothelial growth factor receptor 2/cell therapy/PiggyBac transposase

分类

医药卫生

引用本文复制引用

Tian-Tian Li,Ming-Yao Meng,Zheng Yu,Yang-Fan Guo,Yi-Yi Zhao,Hui Gao,Li-Li Yang,Li-Rong Yang,Meng-Yuan Chu,Shan He,Yuan Liu,Xiao-Dan Wang,Wen-Ju Wang,Zong-Liu Hou,Li-Wei Liao,Lin Li..Investigation on the Anti-Cancer Effects of HER2-Targeted CAR-T Cells Engineered Using the PiggyBac Transposon System[J].Oncology Research,2025,33(11):P.3447-3467,21.

基金项目

supported by the Yunnan Fundamental Research Projects,China(Grant No.202201AS070068) （Grant No.202201AS070068）

Central Funds Guiding the Local Science and Technology Development,China(202207AB110017) （202207AB110017）

The Science and Technology Fund of Kunming City,China(No.2019-1-N-25318000002027) （No.2019-1-N-25318000002027）

The Scientific and Technological Innovation Team in Kunming Medical University,China(CXTD202215). （CXTD202215）

Oncology Research

ISSN：0965-0407

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