Journal of Biomedical Research2025，Vol.39Issue(6)：P.622-638,I0022-I0028,24.DOI:10.7555/JBR.39.20250074
Homoharringtonine exerts anti-silicosis effects by inhibiting the CCR1 and PI3K/AKT signaling pathways in lung fibroblasts
Xinying Jia 1Ziwei Li 1Xiyue Hu 2Ting Wang 3Wenxiu Lian 1Wenqing Sun 4Yi Liu 1Chunhui Ni5
作者信息
- 1. Department of Occupational Medicine and Environmental Health,Key Laboratory of Modern Toxicology of Ministry of Education,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China
- 2. Department of Public Health,Kangda College of Nanjing Medical University,Lianyungang,Jiangsu 222000,China Community Health Service Center of Anzhen Street,Xishan District,Wuxi,Jiangsu 214035,China
- 3. Department of Occupational Medicine and Environmental Health,Key Laboratory of Modern Toxicology of Ministry of Education,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China Department of Pathology,Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School,Nanjing,Jiangsu 210000,China
- 4. The Affiliated Wuxi Center for Disease Control and Prevention of Nanjing Medical University,Wuxi Center for Disease Control and Prevention,Wuxi Medical Center,Nanjing Medical University,Wuxi,Jiangsu 214400,China
- 5. Department of Occupational Medicine and Environmental Health,Key Laboratory of Modern Toxicology of Ministry of Education,School of Public Health,Nanjing Medical University,Nanjing,Jiangsu 211166,China Department of Public Health,Kangda College of Nanjing Medical University,Lianyungang,Jiangsu 222000,China
- 折叠
摘要
关键词
silicosis/homoharringtonine/lung fibroblast/PI3K/AKT/mTOR signaling pathway/CCR1分类
医药卫生引用本文复制引用
Xinying Jia,Ziwei Li,Xiyue Hu,Ting Wang,Wenxiu Lian,Wenqing Sun,Yi Liu,Chunhui Ni..Homoharringtonine exerts anti-silicosis effects by inhibiting the CCR1 and PI3K/AKT signaling pathways in lung fibroblasts[J].Journal of Biomedical Research,2025,39(6):P.622-638,I0022-I0028,24.基金项目
supported by grants from the National Natural Science Foundation of China(Grant Nos.82473601 to Y.L.,82404234 to W.S.,and 82073518 to C.N.) （Grant Nos.82473601 to Y.L.,82404234 to W.S.,and 82073518 to C.N.）
the Foundation of Chongqing Key Laboratory of Prevention and Treatment for Occupational Diseases and Poisoning(Grant No.2022-2023ZYBKF04 to C.N.)。 （Grant No.2022-2023ZYBKF04 to C.N.）
