磁共振成像2025，Vol.16Issue(12)：1-6,29,7.DOI:10.12015/issn.1674-8034.2025.12.001
多模态MRI结合典型相关分析揭示失独父母脑功能异常与临床症状的耦合关系
Multimodal MRI combined with canonical correlation analysis reveals the coupling relationship between brain functional abnormalities and clinical symptoms in parents who have lost their only child
摘要
Abstract
Objective:To investigate the abnormal patterns of brain structure,function,and network in parents who have lost their only child(shidu parents),and to reveal the overall coupling relationship between these abnormalities and clinical symptoms such as depression,anxiety,and post-traumatic stress disorder(PTSD).Materials and Methods:A total of 47 shidu parents(SD)and 36 healthy controls(HC)were included.Multimodal magnetic resonance imaging(MRI)data and clinical symptom ratings were collected from all participants.Voxel-based morphometry(VBM),resting-state functional analysis,and graph-theoretical network analysis were conducted.Canonical correlation analysis(CCA)was further applied to examine the global relationship between multimodal neuroimaging indicators and clinical symptom sets.Results:Compared with the HC group,the SD group showed reduced gray matter volume in brain regions including the left hippocampus,bilateral insula,and left medial and paracingulate gyri(P<0.05,FDR corrected),along with functional abnormalities such as decreased degree centrality in the left temporal lobe(P<0.05,FDR corrected)and increased regional homogeneity in the right middle temporal gyrus(P<0.05,FDR corrected).The topological properties of the brain network were also altered in the SD group(P<0.05,FDR corrected).CCA results demonstrated a significant overall coupling between neuroimaging features and clinical symptoms(canonical correlation coefficient of the first pair:r=0.890,P<0.001).Among the imaging indicators,network properties contributed the most(loading r=-0.998)and were most strongly associated with PTSD symptoms(cross-loading r=-0.882).Conclusions:Shidu parents exhibit widespread brain alterations,with abnormal brain network topology serving as a core neuroimaging feature strongly linked to PTSD and other clinical symptoms.These findings suggest that brain network reorganization may represent a key neural substrate underlying psychological symptoms in this population.关键词
创伤后应激症状/失独父母/磁共振成像/多模态磁共振成像/脑网络分析/典型相关分析Key words
post-traumatic stress symptoms/parents who have lost their only child/magnetic resonance imaging/multimodal magnetic resonance imaging/brain network analysis/canonical correlation analysis分类
医药卫生引用本文复制引用
MAO Yuhong,LU Guangming,LUO Yifeng,CAO Zhihong,LI Yuefeng,GE Jiyuan,LAN Qingyue,QI Rongfeng,WU Luo'an,ZHANG Li..多模态MRI结合典型相关分析揭示失独父母脑功能异常与临床症状的耦合关系[J].磁共振成像,2025,16(12):1-6,29,7.基金项目
National Natural Science Foundation of China(No.81801678) （No.81801678）
Jiangsu Provincial Science and Technology Program(No.BE2022705) （No.BE2022705）
Foundation of Health and Family Planning Commission in Jiangsu Province(No.ZD2022002) （No.ZD2022002）
Wuxi"Double Hundred"Top Talent Support Program for Young and Middle-aged Healthcare Professionals(No.BJ2023103) （No.BJ2023103）
Scientific Research Program of Wuxi Health Commission(No.Q202316).国家自然科学基金项目(编号:81801678) （No.Q202316）
江苏省科技项目(编号:BE2022705) （编号:BE2022705）
江苏省卫生健康委科研项目(编号:ZD2022002) （编号:ZD2022002）
无锡市"双百"中青年医疗卫生拔尖人才培养计划(编号:BJ2023103) （编号:BJ2023103）
无锡市卫生健康委科研项目(编号:Q202316) （编号:Q202316）
