磁共振成像2025，Vol.16Issue(12)：14-21,8.DOI:10.12015/issn.1674-8034.2025.12.003
青少年双相情感障碍患者短期治疗前后大脑默认模式网络功能连接的变化
Default mode network functional connectivity changes in adolescent bipolar disorder patients after short-term treatment
摘要
Abstract
Objective:To investigate changes in default mode network(DMN)functional connectivity(FC)in adolescents with bipolar disorder(BD)after short-term treatment and their correlation with clinical symptoms.Materials and Methods:Thirty patients with BD were enrolled and underwent follow-up assessments after two weeks of naturalistic treatment,along with 33 age-and sex-matched healthy control(HC).Clinical assessments included:the 17-item Hamilton Depression Rating Scale(HAMD-17)for depressive symptoms,the Young Mania Rating Scale(YMRS)for manic symptoms,and the Hamilton Anxiety Rating Scale(HAMA)for anxiety symptoms.Resting-state functional magnetic resonance imaging(rs-fMRI)scans were acquired for all participants at both baseline and the 2-week follow-up timepoint.Using the DMN as seed regions,we performed whole-brain FC analysis.Three primary analyses were conducted:(1)Within-patient longitudinal comparison to identify FC changes between pre-and post-treatment;(2)Between-group cross-sectional comparisons(baseline BD vs.HC;post-treatment BD vs.HC)using two-sample t-tests;(3)Correlation analysis between significant treatment-related FC changes and clinical scale scores.Results:The study found that after two weeks of treatment,the functional connectivity of the posterior cingulate cortex(PCC)in patients changed,showing weakened connectivity with the right calcarine cortex and enhanced connectivity between the posterior cingulate cortex and the left middle occipital gyrus(t=5.79,P=0.001;t=4.72,P=0.004).However,no significant correlations were observed between these changes and clinical scale scores(r=0.183,P=0.466;r=0.238,P=0.342;r=0.086,P=0.684;r=-0.121,P=0.631;r=-0.031,P=0.902;r=-0.213,P=0.308).Compared to the healthy control group,baseline BD patients exhibited abnormalities in the visual network(VN)and the salience network(SN).After treatment,these abnormalities in the VN and SN were not fully resolved,and slight abnormalities emerged in the frontoparietal network(FPN).Conclusions:Short-term treatment can partially modulate the abnormal functional connectivity between the DMN,VN,and SN in BD patients.These neuroimaging findings provide new directions for understanding the neurobiological mechanisms of BD and optimizing early intervention strategies.关键词
双相情感障碍/磁共振成像/功能连接/默认模式网络/视觉网络/突显网络Key words
bipolar disorder/magnetic resonance imaging/functional connectivity/default mode network/visual network/salience network分类
医药卫生引用本文复制引用
ZHU Pengyu,AI Chunqi,CHEN Wen,CHEN Xiong,ZOU Lulu,CHEN Fang,GU Junchen,WANG Yuxi,XIANG Jialin,DENG Xiumin,QIN Kun..青少年双相情感障碍患者短期治疗前后大脑默认模式网络功能连接的变化[J].磁共振成像,2025,16(12):14-21,8.基金项目
Hubei Provincial Natural Science Foundation of China(No.2023AFC033,2024AFB366) （No.2023AFC033,2024AFB366）
Graduate Student Innovation Project of School of Biomedical Engineering,Hubei Medical University(No.SG2025001).湖北省自然科学基金项目(编号:2023AFC033、2024AFB366) （No.SG2025001）
湖北医药学院生物医学工程学院研究生科技创新项目(编号:SG2025001) （编号:SG2025001）
