磁共振成像2025，Vol.16Issue(12)：30-35,6.DOI:10.12015/issn.1674-8034.2025.12.005
双侧突发感音神经性耳聋的类淋巴功能改变与认知-情绪障碍的关系分析:一项结构磁共振成像研究
Glymphatic system alterations and cognitive-emotional impairment in bilateral sudden sensorineural hearing loss:A structural MRI study
摘要
Abstract
Objective:To investigate the neuroimaging mechanisms underlying the association between structural alterations of the glymphatic system and cognitive and emotional impairments in patients with sudden sensorineural hearing loss(SSNHL),using structural magnetic resonance imaging.Materials and Methods:Forty-eight patients with bilateral SSNHL and 47 healthy controls were enrolled.All participants underwent hearing assessments,multidimensional neuropsychological evaluations,and 3D T1-weighted magnetic resonance imaging scans.Choroid plexus volume,perivascular space volume,and ventricular volumes(bilateral,third,and fourth ventricles)were automatically segmented and quantified using a U-net deep learning model and FreeSurfer tool.Spearman correlation analyses were performed to examine the relationships between imaging-derived metrics and cognitive and emotional scores.Results:Patients and healthy controls were well matched in age,sex,and education(P>0.05).Patients showed higher mean binaural hearing thresholds compared to controls,as well as differences in cognitive and depression scale scores(P<0.05).Compared with controls,bilateral SSNHL patients exhibited larger raw and normalized choroid plexus volumes,perivascular space volumes,and bilateral lateral ventricular volumes(P<0.05),while no significant group differences were observed in the raw or normalized volumes of the third and fourth ventricles(P>0.05).Normalized choroid plexus volume was negatively correlated with Symbol Digit Modalities Test performance(r=-0.311,P=0.032)and positively correlated with mean binaural hearing threshold(r=0.382,P=0.007).Conclusions:Bilateral SSNHL is associated with structural alterations in glymphatic system-related brain regions.Enlargement of the choroid plexus is significantly related to reduced information processing speed,providing insight into the neuroimaging mechanisms underlying cognitive and emotional impairments in SSNHL.关键词
突发感音神经性耳聋/结构磁共振成像/类淋巴系统/认知/情绪Key words
sudden sensorineural hearing loss/structural magnetic resonance imaging/glymphatic system/cognition/emotion分类
医药卫生引用本文复制引用
FANG Zihuai,XU Xiaomin,CHEN Yuchen,HUANG Hongjie,YIN Xindao..双侧突发感音神经性耳聋的类淋巴功能改变与认知-情绪障碍的关系分析:一项结构磁共振成像研究[J].磁共振成像,2025,16(12):30-35,6.基金项目
National Natural Science Foundation of China(No.82302162).国家自然科学基金项目(编号:82302162) （No.82302162）
