磁共振成像2025，Vol.16Issue(12)：36-43,58,9.DOI:10.12015/issn.1674-8034.2025.12.006
集成磁共振成像技术在全面发育迟缓儿童脑部中的定量研究
Quantitative study on the brain of children with global developmental delay using synthetic MRI techniques
摘要
Abstract
Objective:Using synthetic MRI(SyMRI)technology to analyze brain microstructural changes in children with global developmental delay and evaluate the diagnostic efficacy of T1 and T2 relaxation values and proton density(PD)values in SyMRI.Materials and Methods:The study was conducted from May 2024 to October 2024,involving 55 children with global developmental delay(GDD group)and 30 typically developing children(TD group)from the Third Affiliated Hospital of Zhengzhou University.SyMRI sequences and clinical data were collected.Post-processing was performed to derive SyMRI parameters,and T1 and T2 relaxation values and PD values were measured in eight gray matter regions of interest(ROIs)for all children.Correlation analyses were performed between the T1,T2,and PD values of brain regions with significant differences and clinical scales.Receiver operating characteristic(ROC)curve analyses were used to evaluate the diagnostic efficacy SyMRI parameters.Results:Compared to the TD group,the GDD group showed increased T1 relaxation values in the left parietal gray matter and right occipital gray matter,T2 relaxation values in the left parietal gray matter and bilateral temporal gray matter,as well as PD values in the left temporal gray matter and right occipital gray matter.These differences were statistically significant(P<0.003).Correlation analyses revealed that the T1 relaxation values in the left parietal gray matter were positively correlated with adaptive behavior developmental quotient(r=0.327,P=0.015)and personal-social developmental quotient(r=0.535,P<0.001).The T2 relaxation values in the left parietal gray matter were positively correlated with adaptive behavior developmental quotient(r=0.449,P=0.001).The T2 relaxation values in the left temporal gray matter were positively correlated with adaptive behavior developmental quotient(r=0.348,P=0.009)and personal-social developmental quotient(r=0.321,P=0.017).The PD values in the left temporal gray matter were positively correlated with fine motor developmental quotient(r=0.322,P=0.017).ROC curve analysis indicated that the T2 relaxation value of left parietal gray matter had the largest area under the curve,at 0.752.Conclusions:SyMRI parameters can indicate abnormal brain microstructure in GDD children,aiding in understanding GDD pathophysiology and offering potential value for early recognition and diagnosis.关键词
全面发育迟缓/集成磁共振成像/磁共振成像/脑微结构/Gesell量表Key words
global developmental delay/synthetic magnetic resonance imaging/magnetic resonance imaging/brain microstructure/Gesell Developmental Scales分类
医药卫生引用本文复制引用
LI Tianyu,ZHAO Xin,ZHOU Liang,WANG Changhao,LU Lin,CHENG Meiying,ZHANG Xiaoan..集成磁共振成像技术在全面发育迟缓儿童脑部中的定量研究[J].磁共振成像,2025,16(12):36-43,58,9.基金项目
National Natural Science Foundation of China(No.82371929,82472046).国家自然科学基金项目(编号:82371929、82472046) （No.82371929,82472046）
