磁共振成像2025，Vol.16Issue(12)：80-86,7.DOI:10.12015/issn.1674-8034.2025.12.012
基于磁共振定量参数与血清学指标联合模型对Graves眼病活动性的应用研究
Study on the application of a combined model based on quantitative magnetic resonance parameters and serological indicators for evaluating the activity of Graves's ophthalmopathy
摘要
Abstract
Objective:To explore the value of orbital parameters combined with serological parameters in the diagnosis of Graves's orbitopathy(GO)activity by quantitative analysis.Materials and Methods:A retrospective collection of 47 patients diagnosed with GO who visited the Endocrinology Department of North China University of Science and Technology Affiliated Hospital from January 2024 to February 2025 was conducted.Patients were divided into active and inactive groups based on Clinical Activity Score(CAS),and a control group consisting of 15 healthy individuals was also collected.All subjects were examined by MRI and serology.The maximal diameter,maximal cross-sectional area,T2 relaxation time(T2RT)and exophthalmos of each extraocular muscle of the three groups were measured respectively,and the clinical data of the three groups were collected.The parameters were statistically analyzed by SPSS 27.0 software,and the parameters with statistical differences were quantified by binary logistic regression combined with MRI.The receiver operating characteristics(ROC)curve was used to evaluate the predictive efficacy of quantitative parameters of extraocular muscles on GO activity,and the area under the curve(AUC)was compared by DeLong method.Spearman's correlation analysis was used to analyze the relationship between imaging parameters and CAS score.Results:The maximal diameter,maximal cross-sectional area,T2RTmax,T2RTmean and exophthalmos in the activity group were statistically significant(P<0.05),and the quantitative parameters in the activity group were significantly increased.ROC curve analysis shows that TRAb,T2RTmax and exophthalmos have the best diagnostic efficacy,which is higher than the single diagnostic value of the three groups.The AUC value is 0.905,the sensitivity is 91.7%,the specificity is 81.0%,and the cutoff value is 0.44.The maximumcross-sectional area(r=0.73,P<0.05),diameter(r=0.70,P<0.05),T2RT(r=0.83,P<0.05)and exophthalmos(r=0.75,P<0.05)were positively correlated with CAS score.Conclusions:Multi-parameters of magnetic resonance imaging and serological indexes can evaluate the activity of GO,and the combination of them can improve the efficacy of clinical diagnosis of GO.关键词
T2 mapping/Graves眼病/定量参数/血清学指标/磁共振成像Key words
T2 mapping/Graves's orbitopathy/quantitative parameter/serological index/magnetic resonance imaging分类
医药卫生引用本文复制引用
LIU Junhong,SHENG Jiaxi,ZHAO Yang,ZHANG Houning..基于磁共振定量参数与血清学指标联合模型对Graves眼病活动性的应用研究[J].磁共振成像,2025,16(12):80-86,7.基金项目
Hebei Province Medical Science Research Project(No.20250952).河北省医学科学研究课题项目(编号:20250952) （No.20250952）
