分析化学2025，Vol.53Issue(11)：1773-1783,11.DOI:10.19756/j.issn.0253-3820.251256
细菌中质粒主动分配系统的研究进展
Progress in Bacterial Plasmid Active Segregation Systems
摘要
Abstract
The faithful segregation of genetic material to daughter cells is a fundamental biological process and a prerequisite for autonomous construction of robustly self-replicating artificial cells.Artificial cells are mimic cell structures with part or whole functions of normal cells.The complexity of eukaryotic chromosome segregation machinery has limited its applications in the field of synthetic biology.In contrast,the plasmid segregation machineries employed by prokaryotes are relatively simple and can provide valuable approaches for the bottom-up construction of complex artificial cells.This review aimed to comprehensively analyze the origin species and working mechanism of three bacterial plasmid segregation systems,namely ParABS,ParMRC,and TubZRC systems.The current researches on plasmid segregation both in bacterial and artificial cellular systems were summarized,and the future directions of this field were also proposed.关键词
细菌质粒分配系统/ParABS系统/ParMRC系统/TubZRC系统/评述Key words
Bacterial plasmid segregation system/ParABS system/ParMRC system/TubZRC system/Review引用本文复制引用
ZHAO Jing-Jing,TIAN Wei-Ming,XU Wei-Li,HAN Xiao-Jun..细菌中质粒主动分配系统的研究进展[J].分析化学,2025,53(11):1773-1783,11.基金项目
国家自然科学基金项目(Nos.W2512010,22374033,22174031)资助. Supported by the National Natural Science Foundation of China(Nos.W2512010,22374033,22174031). （Nos.W2512010,22374033,22174031）
