分析化学2025，Vol.53Issue(11)：1808-1819,12.DOI:10.19756/j.issn.0253-3820.251074
用于连续血糖监测的无创电化学传感器的研究进展
Non-Invasive Electrochemical Sensors for Continuous Glucose Monitoring
摘要
Abstract
Diabetes is one of the top ten fatal diseases globally,and effective diabetes management can significantly reduce the incidence and progression of diabetes-related complications.Traditional blood glucose monitoring relies on fingertip blood sampling to measure glucose concentration,which requires multiple finger pricks per day.However,the long intervals between tests often result in missed hyperglycemic or hypoglycemic events.Therefore,there is an urgent need for non-invasive,continuous,and accurate glucose monitoring technologies to improve patient compliance and provide timely alerts for abnormal glucose levels.Sensors based on electrochemical detection methods,which indirectly estimate glucose levels by analyzing interstitial fluid,sweat,or other bodily fluids,have emerged as a promising direction due to their high sensitivity and low cost.This review focused on recent advancements in non-invasive,continuous glucose monitoring sensors developed using various electrochemical detection methods,with an in-depth analysis of chronoamperometry,impedance spectroscopy,and voltammetry in sensor applications.Finally,the challenges faced by current detection methods in non-invasive continuous glucose monitoring was summarized,and the future directions,including the integration of enzyme-free sensors with deep learning algorithms to enhance accuracy and reliability were proposed.关键词
血糖检测/无创/连续血糖监测/可穿戴设备/评述Key words
Glucose detection/Non-invasive/Continuous glucose monitoring/Wearable devices/Review引用本文复制引用
WANG Jia,DAI Zhen,JIANG De-Chen,QIN Yu..用于连续血糖监测的无创电化学传感器的研究进展[J].分析化学,2025,53(11):1808-1819,12.基金项目
江苏省基础研究专项资金项目(No.BK20210054)资助. Supported by the Natural Science Foundation of Jiangsu Province(No.BK20210054). （No.BK20210054）
