分析化学2025，Vol.53Issue(11)：1828-1838,11.DOI:10.19756/j.issn.0253-3820.251221
高孔隙率共价有机框架微球结合稳定同位素标记技术分析水中烷基酚
Analysis of Alkylphenols in Water Samples Using High Porous Covalent Organic Frameworks Beads in Combination with Stable Isotope Labelling Technology
摘要
Abstract
A pair of positively charged stable isotope labelling agents,4-((2,5-dioxocyclopentyloxy)carbonyl)-N,N,N-trimethylnaphthalen-1-aminium iodide(DPTNA)and its deuterated counterpart d3-DPTNA,were designed and synthesized,which were applied to pre-column labelling of alkylphenols to enhance the sensitivity and accuracy of liquid chromatography-tandem mass spectrometry(LC-MS/MS).By crosslinking covalent organic framework(COF)with hydrophilic sodium alginate and Ca2+in the presence of pore forming agent NH4HCO3 and surfactant P123,abundant of"gas pocket"were created before and during the beads formation process,and high porous COF beads with macroporous and open structure were achieved after removal of gas.Compared with traditional powdered adsorbents,COF beads demonstrated superior operability and recyclability.The proposed method was applied to analysis of alkylphenols in water samples with method LODs of 0.25-0.50 ng/L,while the method LOQs were in the range of 0.80-1.52 ng/L,and recoveries ranged from 92.2%to 98.3%.The proposed method could be well applied to the simultaneous enrichment and analysis of alkylphenols in water samples.关键词
稳定同位素标记/多孔共价有机框架聚合物微球/烷基酚/液相色谱-串联质谱Key words
Stable isotope labelling/High porous crosslinking covalent organic frameworks beads/Alkylphenols/Liquid chromatography-tandem mass spectrometry引用本文复制引用
ZHANG Kai-Yue,SHENG Cun-Cun,ZHANG Shi-Juan,LI Yan-Xin..高孔隙率共价有机框架微球结合稳定同位素标记技术分析水中烷基酚[J].分析化学,2025,53(11):1828-1838,11.基金项目
山东省自然科学基金项目(No.ZR2024MB123)和国家自然科学基金项目(No.318016245)资助. Supported by the Shandong Provincial Natural Science Foundation(No.ZR2024MB123)and the National Natural Science Foundation of China(No.31801624). （No.ZR2024MB123）
