广州医药2025，Vol.56Issue(11)：1511-1518,8.DOI:10.20223/j.cnki.1000-8535.2025.11.006
非霍奇金淋巴瘤患者化疗后感染及平均住院日的影响因素分析
Factors influencing post-chemotherapy infections and length of hospital stay in patients with non-Hodgkin's lymphoma
摘要
Abstract
Objective To explore the effects of nutritional assessment and inflammatory factor levels on post-chemotherapy infections and length of hospital stay in patients with non-Hodgkin's lymphoma(NHL).Methods A total of 95 NHL patients treated with the R-CHOP regimen were retrospectively analyzed.The cut-off value of Patient-Generated Subjective Global Assessment(PG-SGA)for post-chemotherapy infection in NHL patients was evaluated by Receiver Operating Characteristic(ROC)curves.Patients were categorized into PG-SGA<4 and PG-SGA≥4 groups and compared for differences of nutritional and inflammation-related factors.Univariate and multivariate logistic regression were used to analyze the risk factors for post-chemotherapy infection and length of hospital stay(LHS).Results The ROC curve showed that the Youden index was largest at PG-SGA of 3.5,which predicted post-chemotherapy infection in NHL patients with a sensitivity of 92％and a specificity of 11.1％.The mean age,International Prognostic Index(IPI),and Ann Arbor stage Ⅲ～Ⅳ proportion in patients with PG-SGA≥4 were higher compared with the control(P<0.05).Patients with PG-SGA≥4 had significantly higher interleukin-6 and neutrophil-to-lymphocyte ratio(NLR),and the infection rate and the proportion of LHS≥5 days after chemotherapy were higher than those in the control group(P<0.05).Patients in the PG-SGA<4 group had significantly higher prealbumin,albumin,and hemoglobin levels compared to the PG-SGA≥4 group(P<0.05).Multifactorial logistic regression analysis revealed that PG-SGA≥4 and combined diabetes mellitus were independent risk factors for post-chemotherapy infection rate in NHL patients(both P<0.05).Albumin less than 35 g/L and combined post-chemotherapy infection were independent risk factors for prolonged LHS in NHL patients(both P<0.05).Conclusions PG-SGA nutritional assessment and inflammatory factor analysis are clinically instructive in predicting post-chemotherapy infections and LHS in NHL patients.关键词
非霍奇金淋巴瘤/PG-SGA/营养评估/化疗后感染/平均住院日Key words
non-Hodgkin's lymphoma/PG-SGA/nutritional assessment/post-chemotherapy infection/length of hospital stay引用本文复制引用
RONG Chan,WANG Xia,HE Huifang,YANG Li,ZHONG Qingxiu,ZHENG Xin,XU Xin..非霍奇金淋巴瘤患者化疗后感染及平均住院日的影响因素分析[J].广州医药,2025,56(11):1511-1518,8.基金项目
广东省自然科学基金(2022A1515012609) （2022A1515012609）
