广州医药2025，Vol.56Issue(11)：1542-1548,7.DOI:10.20223/j.cnki.1000-8535.2025.11.010
肠腹壁造口对新生儿坏死性小肠结肠炎免疫指标和感染指标的影响
Effect of enterostomy on immune indexes and infection indexes in necrotizing enterocolitis
摘要
Abstract
Objective To investigate the effect of enterostomy on infection indexes and immune indexes in necrotizing enterocolitis,as well as the occurrence of enterostomy and postoperative adverse reactions.Methods Fifty-six neonates who underwent enterostomy for necrotizing enterocolitis in Weifang Maternal and Child Health Hospital from January 2016 to January 2024 were selected as Group A,and 39 neonates who underwent phase I intestinal resection and anastomosis for necrotizing enterocolitis during the same period were selected as Group B.The changes of preoperative and postoperative immune indicators and infection indicators between the two groups of neonates were observed and compared.In addition,40 healthy neonates were selected during the same period,and the differences in immune and infection indexes between group A and healthy neonates were compared before discharge.Patients were followed up after discharge to observe postoperative complications and adverse reactions.Results After surgery,the immune indexes(IgA,IgG,IgM)of the two groups(A and B)were higher than those before surgery,while the infection indexes(IL-6,PCT,TNF-α)were significantly lower than those before surgery.The levels of IgG and IgM in Group A were higher than those in Group B one day before discharge,and the differences were statistically significant(t=2.312,P=0.023;t=3.214,P=0.002).In Group B,the levels of IL-6 on postoperative day two,postoperative day seven,and one day before discharge were significantly higher than in Group A.The differences were statistically significant(t=-4.252,P＜0.001;t=-3.383,P=0.001;t=-2.505,P=0.014).By one day before discharge,the immune indicators and infection indicators of the infants in Group A were not significantly different from those of healthy newborns.No serious complications occurred among all surgical patients during their hospital stay until the enterostomy closure.Conclusions Enterostomy has a good therapeutic effect on neonates with necrotizing enterocolitis,which can reduce the inflammatory response and improve the immune function of children to a certain exten,with better long-term effects and good safety.关键词
肠腹壁造口/坏死性小肠结肠炎/炎症水平/免疫指标Key words
enterostomy/necrotizing enterocolitis/levels of inflammation/immune indexes引用本文复制引用
CHEN Shikai,GUO Tingting,FAN Linlin,YAO Zhejiang,ZHANG Yuhai,ZHANG Jianjun..肠腹壁造口对新生儿坏死性小肠结肠炎免疫指标和感染指标的影响[J].广州医药,2025,56(11):1542-1548,7.基金项目
潍坊市科技发展计划项目(2021YX049) （2021YX049）
