海南师范大学学报（自然科学版）2025，Vol.38Issue(4)：415-422,8.DOI:10.12051/j.issn.1674-4942.2025.04.006
狼毒大戟的化学成分研究
Studies on the Chemical Constituents of Euphorbia fischeriana Steud
摘要
Abstract
Various separation techniques including normal and adverse silica gel and Sephadex LH-20 gel column chram-atography were used to investigate the chemical constituents from Euphorbia fischeriana Steud.Finally,sixteen compounds,including(-)-3,3'-bisdemethylpinoresinol(1),7-epi-sesamin-dicatechol(2),syringaresinol(3),(+)-lariciresinol-9-eico-sanoic acid(4),isoamericanin A(5),N-benzoyl-L-phenylalaninyl-N-benzoyl-L-phenylalaninate(6),(22E)-ergosta-6,9,22-triene-3β,5β,8α-tiol(7),(22E,24R)-5α,8α-epidioxyergosta-6,22-diene-3β-ol(8),(22E,24R)-5α,8α-epidioxy-23-methylergosta-6,22-diene-3β-ol(9),β-sitosterol(10),Schleicheol 1(11),3'-(4''-hydroxy-3''-methoxyphenyl)-propyl benzoate(12),3-hydroxybenzene ethanol(13),N-benzoyl-L-phenyla-laninol(14),crypticin B(15),gallic acid(16)were isolated,and their structures were identified by NMR data and comparison with values reported.Compounds 1,2,4‒7,9,and 12 were isolated from the genus Euphorbia for the first time.Except for 10 and 16,the others were firstly isolated from E.fischeriana Steud.Compound 4 showed obvious inhibitory activity against breast cancer cell line(MCF-7)with IC50 of(11.3±0.34)µmol/L[cisplatin IC50=(6.2±0.20)µmol/L].关键词
大戟科/狼毒大戟/木脂素/甾体Key words
Euphorbiaceae/Euphorbia fischeriana Steud/lignans/steroids分类
医药卫生引用本文复制引用
LIU Hongming,HUANG Yuping,ZENG Guijun,LI Wennan,ZHAO Yong..狼毒大戟的化学成分研究[J].海南师范大学学报（自然科学版）,2025,38(4):415-422,8.基金项目
国家自然科学基金项目(82360694) （82360694）
