海南师范大学学报（自然科学版）2025，Vol.38Issue(4)：423-429,7.DOI:10.12051/j.issn.1674-4942.2025.04.007
肉苁蓉水部位环烯醚萜苷类化学成分
Chemical Constituents of Iridoid Glycosides from the Water Fraction of Cistanche deserticola Y.C.Ma
摘要
Abstract
This study aimed to investigate the highly polar chemical constituents of Cistanche deserticola Y.C.Ma and evaluate their antibacterial activities against methicillin-resistant Staphylococcus aureus(MRSA).Compounds were isolated through column chromatography(silica gel,MCI gel CHP-20,ODS,and Sephadex LH-20)and purified via preparative HPLC.Structural elucidation was achieved using spectroscopic analysis(MS,1HNMR,13C NMR)and comparison with literature data.Eleven compounds were identified as 6-deoxycatalpol(1),bartsioside(2),gluroside(3),kankanoside B(4),catalpol(5),dihydrocatalpol(6),ajugol(7),monomelittoside(8),aucubin(9),kankanoside A(10),and kankanoside L(11).Compounds 5,6,8,and 9 were reported for the first time in Cistanche deserticola Y.C.Ma.Anti-MRSA evaluation revealed that compounds 4 and 11 exhibited significant inhibitory effects,with MIC50 values of 56.7 µmol/L and 77.2 µmol/L,and MIC90 values of 106.6 µmol/L and 147.6 µmol/L,respectively.关键词
肉苁蓉/化学成分/提取分离/抗MRSA活性Key words
Cistanche deserticola/chemical constituents/separation/anti-MRSA分类
医药卫生引用本文复制引用
JIANG Cheng,FANG Shai,LOU Yu,LYU Le,CHEN Ruiyun..肉苁蓉水部位环烯醚萜苷类化学成分[J].海南师范大学学报（自然科学版）,2025,38(4):423-429,7.基金项目
广东省普通高校工程技术研究中心项目(2024GCZX016) （2024GCZX016）
深圳城市职业学院校级课题(2411012) （2411012）
