海南师范大学学报（自然科学版）2025，Vol.38Issue(4)：430-434,5.DOI:10.12051/j.issn.1674-4942.2025.04.008
红树来源真菌Talaromyces sp.23061902次级代谢产物与生物活性
Secondary Metabolites and Their Bioactivities from Mangrove-Derived Fungus Talaromyces sp.23061902
摘要
Abstract
This study investigated the secondary metabolites and their bioactivities of a medicinal mangrove-derived fun-gus Talaromyces sp.23061902.The secondary metabolites were isolated and purified by forward and reverse-phase silica gel column chromatography,Sephadex LH-20 gel column chromatography,semi-preparative HPLC and other chromato-graphic separation methods.The structures were identified through comprehensive NMR,MS,and other spectral analysis methods,and compared with the data reported in literature.The obtained compounds were evaluated in terms of ABTS radi-cal scavenging activity and anti-phytopathogenic activity.Seven known compounds were isolated and identified from fun-gus Talaromyces sp.23061902,including three benzene derivatives,5-dimethylbenzene-1,3-diol(1),2-hydroxy-,4,6-tri-methylbenzoic acid(2),4-dihydroxy-,6-dimethylbenzoic acid(3),and four polyketone compounds such as polyketides pe-nisimplicissin(4),dihydrovermistatin(5),aspergillumarin A(6),and penipyranicin B(7).The bioactivity assays revealed that the crude extract,compounds 1 and 7 exhibited antioxidant activities with IC50 values of 62.5,18.2 and 13.5 µg/mL,re-spectively,compared with the vitamin C in control group showing the IC50 value of 10.0 µg/mL.The crude extract and com-pound 1 exhibited significant inhibitory activity against Xanthomonas oryzae pv.oryzae,with minimum inhibitory concentra-tion(MIC)of 100 µg/mL and 6.25 µg/mL,respectively.Notably,compound 1 demonstrated superior potency compared to Zhongshengmycin in positive control(MIC,12.5 µg/mL).关键词
药用红树/Talaromyces sp./次级代谢产物/抗氧化活性/抗农业致病菌活性Key words
medicinal mangrove plant/Talaromyces sp./secondary metabolites/antioxidant activity/antiphytopathogenic activity分类
医药卫生引用本文复制引用
CHEN Shiji,YU Miao,SHI Jueying,HUANG Guolei,LI Shichuan,ZHENG Caijuan..红树来源真菌Talaromyces sp.23061902次级代谢产物与生物活性[J].海南师范大学学报（自然科学版）,2025,38(4):430-434,5.基金项目
国家自然科学基金(32160108) （32160108）
海南省院士创新平台科研专项资金(YSPTZX202309) （YSPTZX202309）
