海南医科大学学报2025，Vol.31Issue(23)：1833-1840,8.DOI:10.13210/j.cnki.jhmu.20250627.002
少突胶质细胞与α-突触核蛋白在脱髓鞘疾病中的研究进展
Research progress of oligodendrocytes and α-synuclein in demyelinating diseases
摘要
Abstract
Demyelinating diseases are characterized by demyelination,accompanied by abnormal nerve conduction caused by neuronal and axonal injury.In the central nervous system,oligodendrocytes are responsible for myelin formation,and their dys-function is closely related to the pathological aggregation of α-synuclein.The soluble protein misfolds under pathological condi-tions,interferes with oligodendrocyte function through oligomerization deposition,and then causes demyelination and white matter damage.This article focuses on the molecular mechanism of α-synuclein misfolding and its pathological aggregation in oligodendro-cytes,and discusses the mechanism of the influence of related hypotheses on the occurrence and development of demyelinating dis-eases,in order to provide new intervention targets for clinical treatment.关键词
脱髓鞘/少突胶质细胞/α-突触核蛋白Key words
Demyelination/Oligodendrocytes/α-synuclein分类
医药卫生引用本文复制引用
GUO Jingxin,HAN Jingxian,ZHANG Xuezhu..少突胶质细胞与α-突触核蛋白在脱髓鞘疾病中的研究进展[J].海南医科大学学报,2025,31(23):1833-1840,8.基金项目
This study was supported by the National Natural Science Foundation of China(82174492,30630074) 国家自然科学基金资助项目(82174492,30630074) （82174492,30630074）
