实用临床医药杂志2025，Vol.29Issue(22)：1-8,8.DOI:10.7619/jcmp.20255186
色氨酸代谢在癌症研究中的演进趋势:文献计量与可视化分析
Research trend of tryptophan metabolism in cancer:the bibliometric and visual analyses
摘要
Abstract
Objective To explore the evolutionary trends,research hotspots,and cutting-edge areas of tryptophan metabolism in cancer research.Methods Based on the Web of Science Core Collection,relevant English-language literatures published from January 2005 to July 2024 were re-trieved,with a total of 1 927 articles included.Tools such as CiteSpace and VOSviewer were used to conduct visual analyses of the number of publications,countries,institutions,authors,journals,key-words,and co-cited references.Results The overall annual number of publications showed an upward trend,reaching a peak in 2021.America and China were the primary research forces,the representative institution was the Medical University of Innsbruck,and the highly productive author was Dietmar Fuchs.Keyword analysis indicated that research hotspots were concentrated on indoleam-ine 2,3-dioxygenase(IDO),dendritic cells,tumor immunity,and metabolic pathways.In recent years,a sustained increase was found in the popularity of areas such as gut microbiota,tumor micro-environment,and immunotherapy.Conclusion Researches on tryptophan metabolism in cancer have gradually deepened,and future trends will focus on the cross-integration of multiple metabolic pathways and immune regulatory mechanisms,particularly in the exploration of tumor microenvironment and immunotherapy targets.关键词
色氨酸代谢/犬尿氨酸/肿瘤微环境/免疫治疗/芳香烃受体/吲哚胺2,3-双加氧酶/肠道菌群/文献计量学Key words
tryptophan metabolism/kynurenine/tumor microenvironment/immunotherapy/aryl hydrocarbon receptor/indoleamine 2,3-dioxygenase/gut microbiota/bibliometric分类
医药卫生引用本文复制引用
MA Huanhuan,DING Ran,WANG Junwen,DU Guangying,ZHANG Yun,LU Qiuchen,HOU Yingyue,CHEN Haosong,JIAO Hongguan..色氨酸代谢在癌症研究中的演进趋势:文献计量与可视化分析[J].实用临床医药杂志,2025,29(22):1-8,8.基金项目
国家重点研发计划子课题(2020YFC2006002-03) （2020YFC2006002-03）
