ZHAO Xing 1GUO Qi 1HU Guolong 1GUI Xia 1ZHAO Gang 1MA Xiumin1
作者信息
- 1. @@@1.Department of Blood Transfusion,3.Center of Clinical Laboratory,Cancer Hospital Affiliated to Xinjiang Medical University,Urumqi,Xinjiang,830011||2.Department of Blood Transfusion,Hospital of Traditional Chinese Medicine Affiliated to Xinjiang Medical University,Urumqi,Xinjiang,830054
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摘要
Abstract
Objective To investigate the efficacy of thromboelastography(TEG)combined with D-dimer(D-D)and fibrinogen(Fib)in predicting venous thromboembolism(VTE)in patients with gastric cancer.Methods Based on the inclusion and exclusion criteria,clinical data from 150 pa-tients with gastric cancer in the Tumor Hospital Affiliated to Xinjiang Medical University from January 2022 to December 2023 were collected.The patients were divided into thrombus group(n=29)and non-thrombus group(n=121)according to their thrombotic status.TEG parameters[reaction time(R value),coagulation time(K value),clot angle(α angle),and maximum amplitude(MA)val-ue]as well as Fib and D-D levels were compared between the two groups.Logistic regression analysis and receiver operating characteristic(ROC)curve were used to evaluate the predictive value of each indicator alone and their combination for VTE.Results No significant differences were observed be-tween the thrombus and non-thrombus groups in terms of age,gender,ethnicity,pathological type,degree of infiltration,lymph node metastasis,distant metastasis,and Khorana score(P＞0.05).Significant differences were observed in TEG parameters(R value,K value,α angle,and MA value)and conventional coagulation indicators(Fib and D-D levels)between the two groups(P＜0.05).Logistic regression model analysis revealed that R value,K value,α angle,MA value,Fib and D-D were relevant risk factors for thrombosis in patients with gastric cancer(P＜0.05).The area under the curve(AUC)for MA value in predicting VTE was 0.931,with a sensitivity of 0.909 and a spe-cificity of 0.862,making it the optimal single indicator.The AUC for the combined prediction of all indicatorswas 0.940,with a sensitivity of 0.759 and a specificity of 0.967.Conclusion TEG combined with D-D and Fib exhibits a synergistic effect in predicting VTE in patients with gastric cancer,and MA value can serve as a high-precision independent predictive marker.关键词
胃癌/静脉血栓栓塞症/血栓弹力图/D-二聚体/纤维蛋白原/最大振幅/曲线下面积/协同效应Key words
gastric cancer/venous thromboembolism/thromboelastography/D-dimer/fi-brinogen/maximum amplitude/area under the curve/synergistic effect分类
医药卫生
