菌物学报2025，Vol.44Issue(12)：1-20,20.DOI:10.13346/j.mycosystema.250183
链格孢霉所致皮肤及皮肤结构感染
Cutaneous alternariosis:a review of literatures
摘要
Abstract
Alternaria species can induce multisystem infections in humans,and infections of the skin and skin structures(cutaneous alternariosis)can come in a variety of forms and be easily misdiagnosed.It is crucial to investigate the manifestation of alternariosis,the species of Alternaria spp.,and susceptibility.By searching Pubmed,Wanfang,and Chinese full-text journal databases for case reports,descriptive analysis was performed to construct a database.In total,58 publications appeared during 2010-2022 involving 74 patients were obtained.The major risk factors were organ transplantation,hematologic malignancies,trauma history,and occupational exposure.The infections were caused by ten pathogenic species,the most prevalent of which was Alternaria infectoria group(33.8%)including A.anthropophila,A.atrobrunnea,and A.guarroi,followed by A.alternata(28.4%).A.arborescens,A.chlamydospora,A.rosae,A.tenuissima,and A.triticina are less common pathogens.The predominant manifestation of the skin lesions was skin mass,including nodules,tumors,plaques,papules,etc.Granulomas is the main performance of histopathology.The fungi of this genus are susceptible to posaconazole and itraconazole.Drug-resistance of infection strains is on the rise.The manifestations of cutaneous alternariosis can simulate a variety of diseases.Few cases involving immune abnormality or deep tissue infection warrant special attention.关键词
真菌感染/皮肤结构感染/暗色丝孢霉病/链格孢/链格孢霉病Key words
fungal infection/skin structure infection/phaeohyphomycosis/Alternaria species/alternariosis引用本文复制引用
CHEN Anxin,LI Dongming..链格孢霉所致皮肤及皮肤结构感染[J].菌物学报,2025,44(12):1-20,20.基金项目
国家重点研发计划(2022YFC2504800 to DML) （2022YFC2504800 to DML）
国家自然科学基金(32070019,31770013 to DML)This work was supported by the National Key Research and Development Program of China(2022YFC2504800 to DML)and the National Natural Science Foundation of China(32070019,31770013 to DML). （32070019,31770013 to DML）
