菌物学报2025，Vol.44Issue(12)：30-59,30.DOI:10.13346/j.mycosystema.250041
银屑病与真菌感染
Psoriasis and fungal infections
摘要
Abstract
Psoriasis is a chronic,recurrent,and refractory dermatosis.Due to impaired skin barrier function,the pathogenic fungi generally can be isolated from psoriatic lesions.With the widespread use of immunosuppressants,particularly biologics,in the treatment of psoriasis,the incidence of fungal infections in patients with psoriasis is increasing.However,the role of fungal infections in the onset,progression,and prognosis of psoriasis remains unclear,and a systematic understanding of fungal species diversity in psoriasis is lacking.In this paper,relevant literature from Medline and Chinese academic databases was systematically reviewed and analyzed,providing a comprehensive summary of the fungal species associated with psoriasis and their impact on disease burden.The fungal species reported in psoriasis include Candida spp.,Trichophyton spp.,Aspergillus spp.,Malassezia spp.,Scedosporium spp.,Exophiala spp.,Histoplasma spp.,Cryptococcus spp.,Mucor spp.,Pneumocystis spp.,as well as recently reported species such as Fusarium spp.and Stemphylium spp.These fungi play roles in inducing,exacerbating,and influencing the prognosis of psoriasis and may even mimic psoriatic lesions.Therefore,routine fungal infection screening was recommended before initiating immunosuppressive therapy in psoriasis patients,particularly before the use of TNF-α inhibitors,IL-17 inhibitors,and methotrexate.关键词
真菌多样性/真菌菌群紊乱/银屑病/真菌病Key words
fungal diversity/mycobiome dysbiosis/psoriasis/mycoses引用本文复制引用
LO Houman,LI Dongming..银屑病与真菌感染[J].菌物学报,2025,44(12):30-59,30.基金项目
国家自然科学基金(32270002,31770013)This work was supported by the National Natural Science Foundation of China(32270002,31770013). （32270002,31770013）
