菌物学报2025，Vol.44Issue(12)：128-136,9.DOI:10.13346/j.mycosystema.250235
肾移植术后疣状瓶霉感染致暗色丝孢霉病一例
Phaeohyphomycosis caused by Phialophora verrucosa in a renal transplant recipient:a case report
CUI Yinling 1BAI Yongsheng 1CHEN Mei 1QIN Xuyan 1ZHENG Weiqing1
作者信息
- 1. Qingdao Traditional Chinese Medicine Hospital,Qingdao Hiser Hospital Affiliated to Qingdao University,Qingdao 266033,Shandong,China
- 折叠
摘要
Abstract
Phialophora verrucosa infection can cause phaeohyphomycosis and chromoblastomycosis,with cutaneous lesions often presenting as black proliferation.Diagnosis and treatment are particularly challenging,especially in immunocompromised patients.In this paper,a case of phaeohyphomycosis caused by P.verrucosa infection in a post-renal transplant patient is reported.The patient was a 66-year-old male farmer presenting a plaque on the lateral aspect of the right hand for four months.He underwent renal transplantation 15 years ago and had been receiving long-term oral immunosuppressive therapy with tacrolimus,mycophenolate mofetil,and prednisone.Histopathological examination revealed a large infiltration of inflammatory cells and multinucleated macrophages,along with brown,round,thick-walled spores and pigmented septate hyphae.Culture on Sabouraud dextrose agar produced black velvety colonies,and microscopic examination showed pigmented,branched,and septate hyphae.Slide cultures demonstrated phialide structures resembling bouquets;the phialides were flask-shaped or elliptical,producing oval conidia;the conidia aggregated in clusters around the phialide apex,resembling a flower.The morphological features were consistent with those of P.verrucosa.The illness was diagnosed as phaeohyphomycosis.Oral itraconazole was administered and the dose of the immunosuppressant tacrolimus was reduced.Six months later,the cutaneous lesions largely resolved.The skin lesions caused by P.verrucosa infection are usually black in color,and are often clinically misdiagnosed as malignant melanoma.Timely identification of the pathogen and initiation of antifungal therapy are critical for successful treatment,and it is essential to appropriately reduce immunosuppressive agents in renal transplant recipients.关键词
疣状瓶霉/暗色丝孢霉病/肾移植术后Key words
Phialophora verrucosa/phaeohyphomycosis/renal transplantation引用本文复制引用
CUI Yinling,BAI Yongsheng,CHEN Mei,QIN Xuyan,ZHENG Weiqing..肾移植术后疣状瓶霉感染致暗色丝孢霉病一例[J].菌物学报,2025,44(12):128-136,9.
