临床肝胆病杂志2025，Vol.41Issue(11)：2235-2239,5.DOI:10.12449/JCH251106
代谢与酒精相关性肝病:一个新的肝病实体
Metabolic and alcohol-associated liver disease:A novel liver disease entity
摘要
Abstract
The term"metabolic and alcohol-related liver disease(MetALD)"recently proposed emphasizes the synergistic role of metabolic dysfunction and alcohol exposure in the progression of liver injury.Although this theoretical framework improves the understanding of the multifactorial and complex nature of liver disease,its clinical application still faces numerous new challenges in diagnosis and treatment.This article summarizes the latest evidence for the prevalence,potential pathogenesis,clinical diagnostic markers,and treatment of MetALD and particularly emphasizes the urgency to develop reliable preclinical models that can accurately simulate the intricate pathophysiology of this disease due to various factors.This article also provides a systematic evaluation of emerging therapies including fecal microbiota transplantation and nutritional interventions and proposes the future directions for drug innovation in MetALD.关键词
代谢与酒精相关性肝病/诊断/治疗学Key words
Metabolic and Alcohol-Associated Liver Disease/Diagnosis/Therapeutics引用本文复制引用
FENG Yue,XU Hongqin,HAN Panshili,LIU Tao,GAO Yanhang..代谢与酒精相关性肝病:一个新的肝病实体[J].临床肝胆病杂志,2025,41(11):2235-2239,5.基金项目
国家自然科学基金(U24A20654,82170602) （U24A20654,82170602）
吉林省自然科学基金自由探索重点项目(YDZJ202401427ZYTS) （YDZJ202401427ZYTS）
吉林省肝脏代谢重点实验室(YDZJ202502CXJD002) National Natural Science Foundation of China(U24A20654,82170602) （YDZJ202502CXJD002）
Natural Science Foundation for Self-exploration Research of Jilin Province(YDZJ202401427ZYTS) （YDZJ202401427ZYTS）
Jilin Provincial Key Laboratory of Metabolic Liver Diseases(YDZJ202502CXJD002) （YDZJ202502CXJD002）
