日用化学品科学2025，Vol.48Issue(12)：9-14,6.DOI:10.3969/j.issn.1006-7264.2025.12.002
不同浓度光甘草定对美白功效的影响研究
Study on the whitening efficacy of glycyrrhizin at different concentrations
JIANG Mingrui 1LIN Shaoping 1FENG Shiyun 2YAN Yongtao2
作者信息
- 1. Perfect(China)Co.,Ltd.,Zhongshan,Guangdong 528400,China
- 2. Perfect(Guangdong)Daily Products Co.,Ltd.,Zhongshan,Guangdong 528400,China||Guangdong Perfect Life Health Technology Research Institute Co.,Ltd.,Zhongshan,Guangdong 528400,China
- 折叠
摘要
Abstract
The whitening efficacy of two whitening lotions containing different concentrations of glycyrrhizin was evaluated using mushroom tyrosinase assays,B16F10 melanoma cell models,zebrafish models,and human clinical studies.In vitro results showed that both formulations significantly inhibited melanin production in B16F10 cells and zebrafish.Compared with the 0.1%glycyrrhizin lotion,the 1%formulation exhibited stronger inhibitory activity against mushroom tyrosinase and more effectively reduced melanin synthesis in cellular and zebrafish models.Human efficacy studies confirmed that the 0.1%formulation met the registration requirements for spot-lightening and whitening cosmetics based on ITA° and MI values.The 1%formulation met all three evaluation criteria—visual skin tone assessment,ITA°,and MI values—demonstrating faster and more pronounced skin tone improvement.关键词
光甘草定/美白/黑色素/酪氨酸酶/人体功效研究Key words
glycyrrhizin/whitening/melanin/tyrosinase/human efficacy study分类
化学化工引用本文复制引用
JIANG Mingrui,LIN Shaoping,FENG Shiyun,YAN Yongtao..不同浓度光甘草定对美白功效的影响研究[J].日用化学品科学,2025,48(12):9-14,6.
